Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | KIF11 | P52732 | 5/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | LAP3 | P28838 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16148829 | 1.00 | LMNA (0.38) | LMNAKIF11ANPEPLAP3KDM4E | |
| SCHEMBL9752682 | 0.78 | KIF11 (0.42) | LMNAKIF11KDM4EMAPK1MAOA | |
| SCHEMBL4421575 | 0.75 | KIF11 (0.45) | LMNAKIF11KCNH2SMN1; SMN2 | |
| SCHEMBL16062155 | 0.75 | ALDH1A1 (0.41) | LMNAKIF11KDM4EADRA2AADRA2C | |
| SCHEMBL28227393 | 0.72 | TRPA1 (0.40) | LMNAKIF11KDM4EMAPK1GRIN1 | |
| SCHEMBL5899999 | 0.72 | ALDH1A1 (0.39) | LMNAKIF11KDM4EADRA2AADRA2C | |
| SCHEMBL4367368 | 0.71 | MAPK1 (0.42) | KIF11CYP2D6CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL1487205 | 0.71 | LMNA (0.52) | LMNAKIF11CYP2D6CYP1A2ALDH1A1 | |
| SCHEMBL9668861 | 0.71 | KIF11 (0.47) | KIF11CYP2D6CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL3529955 | 0.71 | TRPA1 (0.38) | LMNAKIF11HIF1ACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970312-A1 | BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | The Regents of The University of Michigan (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014164596-A1 | BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-09 | — | — | WO | disclosed |