Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.41 |
| ▸ | ESR1 | P03372 | 12/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364151 | 0.74 | ALDH1A1 (0.43) | ALDH1A1CYP3A4LMNACYP1A2CYP2C9 | |
| SCHEMBL6056629 | 0.72 | CYP3A4 (0.42) | ALDH1A1CYP3A4LMNACYP1A2CYP2C9 | |
| SCHEMBL4415462 | 0.71 | ESR2 (0.48) | ESR2ESR1MMP3BCL2L1HSD17B1 | |
| SCHEMBL4420088 | 0.66 | ESR2 (0.44) | ALDH1A1MAPTHPGDESR2ESR1 | |
| Pentane SCHEMBL28008464 | 0.65 | HSD17B1 (0.73) | CYP3A4CYP1A2CYP2C9CYP2C19ESR2 | |
| Hydrochloric Acid SCHEMBL31313327 | 0.65 | PTPN1 (0.37) | ALDH1A1CYP3A4LMNACYP1A2CYP2C9 | |
| SCHEMBL313685 | 0.64 | ACHE (0.55) | CYP3A4LMNATP53KCNH2 | |
| Butane SCHEMBL2769411 | 0.64 | MMP3 (0.75) | LMNAMAPTHPGDRAB9AESR2 | |
| SCHEMBL13303151 | 0.64 | DYRK1A (0.44) | ALDH1A1CYP3A4LMNACYP1A2CYP2C9 | |
| Oxyphenbutazone Anhydrous SCHEMBL25856 | 0.62 | LMNA (1.00) | ALDH1A1CYP3A4LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326018-A1 | 2-Phenyl indene derivatives useful as estrogen receptor ligands | KARO BIO AB (SE) | 2009-12-31 | — | — | US | claimed |
| US-20090326018-A1 | 2-Phenyl indene derivatives useful as estrogen receptor ligands | KARO BIO AB (SE) | 2009-12-31 | — | — | US | disclosed |
| US-20090326018-A1 | 2-Phenyl indene derivatives useful as estrogen receptor ligands | KARO BIO AB (SE) | 2009-12-31 | — | — | US | disclosed |
| WO-2008043567-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326018-A1 | 2-Phenyl indene derivatives useful as estrogen receptor ligands | ESR1, GPER1, ESR2 | ALDH1A1 1020/4885CYP3A4 885/4885LMNA 2411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.