Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027376 | 0.89 | CCR2 (0.43) | CCR2CCR5CNR1ALDH1A1F10 | |
| SCHEMBL4421314 | 0.89 | CCR2 (0.38) | CCR2CCR5 | |
| SCHEMBL4417824 | 0.88 | FFAR2 (0.33) | CCR2CCR5 | |
| SCHEMBL4426067 | 0.88 | CNR1 (0.40) | CCR2CCR5CNR1ALDH1A1CNR2 | |
| SCHEMBL4416754 | 0.88 | KMT2A (0.31) | ALDH1A1F10CSNK2A2CSNK2A1KMT2A | |
| SCHEMBL4424140 | 0.84 | IRAK4 (0.41) | CCR2CNR1 | |
| SCHEMBL4551359 | 0.84 | NSD2 (0.47) | NSD2 | |
| SCHEMBL4417401 | 0.84 | IRAK4 (0.39) | CCR2CCR5CNR1CNR2 | |
| SCHEMBL4421724 | 0.83 | F10 (0.36) | CCR2CCR5CNR1F10KMT2A | |
| SCHEMBL4416711 | 0.83 | CNR1 (0.37) | CCR2CCR5CNR1CNR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |