Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.75 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.60 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8508344 | 0.98 | AOC3 (0.73) | AOC3TAAR1ACHECALM1CAMKK2 | |
| SCHEMBL555038 | 0.89 | AOC3 (0.66) | AOC3TAAR1ACHECALM1CAMKK2 | |
| SCHEMBL18122711 | 0.89 | AOC3 (0.75) | AOC3TAAR1CALM1CAMKK2CHRM2 | |
| SCHEMBL4680668 | 0.84 | AOC3 (0.69) | AOC3TAAR1ACHECALM1CAMKK2 | |
| SCHEMBL723511 | 0.84 | TAAR1 (0.77) | AOC3TAAR1HTR1ACHRM2CHRM1 | |
| SCHEMBL30080050 | 0.84 | TAAR1 (0.77) | AOC3TAAR1HTR1ACHRM2CHRM1 | |
| SCHEMBL4680665 | 0.83 | AOC3 (0.67) | AOC3TAAR1CALM1CAMKK2CHRM2 | |
| SCHEMBL3066066 | 0.82 | ACHE (0.59) | AOC3TAAR1ACHEHTR7HTR1A | |
| SCHEMBL5271881 | 0.82 | AOC3 (0.66) | AOC3TAAR1ACHECALM1CAMKK2 | |
| SCHEMBL13801215 | 0.82 | AOC3 (0.65) | AOC3TAAR1ACHECALM1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102285904-B | Method for preparing rivastigmine | CHENGDU INST BIOLOGY CAS | 2013-06-05 | — | — | CN | claimed |
| CN-102285904-A | Method for preparing rivastigmine | — | 2011-12-21 | — | — | CN | claimed |
| WO-2011070585-A1 | PROCESSES FOR PREPARING RIVASTIGMINE, SALTS AND INTERMEDIATES THEREOF | SHODHANA LABORATORIES LIMITED (IN) | 2011-06-16 | — | — | WO | claimed |
| US-20230174690-A1 | COMPOSITIONS AND METHODS FOR SINGLE-STEP MULTIPURPOSE SURFACE FUNCTIONALIZATION | UNIV RUTGERS (US) | 2023-06-08 | — | — | US | disclosed |
| US-9783500-B2 | 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2017-10-10 | — | — | US | disclosed |
| US-9663468-B2 | 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160368877-A1 | 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-22 | — | — | US | disclosed |
| US-20160096806-A1 | 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-07 | — | — | US | disclosed |
| US-9212144-B2 | 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150210644-A1 | 2-AMINOQUINOLINE-BASED COMPOUNDS FOR POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITION | NORTHWESTERN UNIVERSITY | 2015-07-30 | — | — | US | disclosed |
| CN-102285904-B | Method for preparing rivastigmine | CHENGDU INST BIOLOGY CAS | 2013-06-05 | — | — | CN | disclosed |
| EP-2220100-A2 | CHIRAL CYCLOPLATINIZED COMPLEXES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINE AND CATALYSTS | Rheinisch-Westfälisch-Technische Hochschule Aachen (DE) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009077462-A2 | CHIRAL CYCLOPLATINIZED COMPLEXES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINE AND CATALYSTS | Rheinisch-Westfälische Technische Hochschule Aachen (DE) | 2009-06-25 | — | — | WO | disclosed |
| EP-2054373-A1 | IMPROVED PROCESS FOR THE PREPARATION OF RIVASTIGMINE | Alembic Limited (IN) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008020452-A1 | IMPROVED PROCESS FOR THE PREPARATION OF RIVASTIGMINE | ALEMBIC LIMITED (IN) | 2008-02-21 | — | — | WO | disclosed |
| EP-1556338-A1 | A METHOD OF PRODUCTION OF (-)-(S)-3- 1-(DIMETHYLAMINO)ETHYL& rsqb;PHENYL-N-ETHYL-N-METHYLCARBAMATE | Zentiva, A.S. (CZ) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037771-A1 | A METHOD OF PRODUCTION OF (-)-(S)-3-[1-(DIMETHYLAMINO)ETHYL]PHENYL-N-ETHYL-N-METHYLCARBAMATE | ZENTIVA, A.S. (CZ) | 2004-05-06 | — | — | WO | disclosed |
| WO-2003101917-A2 | A PROCESS FOR THE PREPARATION OF PHENYLCARBAMATES | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2003-12-11 | — | — | WO | disclosed |
| EP-0901459-A1 | CALCILYTIC COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997037967-A1 | CALCILYTIC COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1997-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368877-A1 | 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition | NOS2, NOS3, NOS1 | AOC3 483/4885TAAR1 797/4885ACHE 104/4885 |
| US-20150210644-A1 | 2-AMINOQUINOLINE-BASED COMPOUNDS FOR POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITION | NOS2, NOS3, NOS1 | AOC3 483/4885TAAR1 797/4885ACHE 104/4885 |
| US-20160096806-A1 | 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition | NOS2, NOS3, NOS1 | AOC3 483/4885TAAR1 797/4885ACHE 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.