Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 11/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16865423 | 0.84 | ELANE (0.58) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17716270 | 0.84 | ELANE (0.87) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17716273 | 0.82 | ELANE (0.89) | ELANENPSR1 | |
| SCHEMBL16867613 | 0.80 | ELANE (0.54) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16865407 | 0.80 | ELANE (0.54) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16865396 | 0.79 | ELANE (0.53) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16865424 | 0.79 | ELANE (0.53) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16865418 | 0.77 | ELANE (0.51) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16867647 | 0.77 | ELANE (0.51) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2044288 | 0.77 | ELANE (0.56) | ELANEALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081576-A2 | METHOD OF IMPROVING BIOAVAILABILITY FOR NON-SEDATING BARBITURATES | Taro Pharmaceuticals North America, Inc. (KY) | 2009-07-29 | — | — | EP | claimed |
| WO-2008066704-A2 | METHOD OF IMPROVING BIOAVAILABILITY FOR NON-SEDATING BARBITURATES | TARO PHARMACEUTICALS NORTH AMERICA, INC. (KY) | 2008-06-05 | — | — | WO | claimed |
| US-20080132529-A1 | Method of improving bioavailability for non-sedating barbiturates | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-06-05 | — | — | US | claimed |
| CN-1291720-C | Non-sedating barbituric acid derivatives | TARO PHARMA IND (IL) | 2006-12-27 | — | — | CN | claimed |
| EP-1485101-A4 | NON-SEDATING BARBITURIC ACID DERIVATIVES | TARO PHARMA IND (IL) | 2006-04-12 | — | — | EP | claimed |
| US-6939873-B2 | Non-sedating barbituric acid derivatives | TARO PHARMACEUTICALS INDUSTRIES LIMITED (IL) | 2005-09-06 | — | — | US | claimed |
| CN-1625401-A | Non-sedating barbituric acid derivatives | TARO PHARMA IND (IL) | 2005-06-08 | — | — | CN | claimed |
| EP-1485101-A1 | NON-SEDATING BARBITURIC ACID DERIVATIVES | Taro Pharmaceutical Industries Limited (IL) | 2004-12-15 | — | — | EP | claimed |
| US-20030187005-A1 | Non-sedating barbituric acid derivatives | TARO PHARMACEUTICAL INDUSTRIES LTD. | 2003-10-02 | — | — | US | claimed |
| WO-2003063872-A1 | NON-SEDATING BARBITURIC ACID DERIVATIVES | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-08-07 | — | — | WO | claimed |
| EP-2081576-A2 | METHOD OF IMPROVING BIOAVAILABILITY FOR NON-SEDATING BARBITURATES | Taro Pharmaceuticals North America, Inc. (KY) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008066704-A2 | METHOD OF IMPROVING BIOAVAILABILITY FOR NON-SEDATING BARBITURATES | TARO PHARMACEUTICALS NORTH AMERICA, INC. (KY) | 2008-06-05 | — | — | WO | disclosed |
| US-20080132529-A1 | Method of improving bioavailability for non-sedating barbiturates | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-06-05 | — | — | US | disclosed |
| US-20080132529-A1 | Method of improving bioavailability for non-sedating barbiturates | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-06-05 | — | — | US | disclosed |
| US-20080132529-A1 | Method of improving bioavailability for non-sedating barbiturates | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-06-05 | — | — | US | disclosed |
| US-6939873-B2 | Non-sedating barbituric acid derivatives | TARO PHARMACEUTICALS INDUSTRIES LIMITED (IL) | 2005-09-06 | — | — | US | disclosed |
| CN-1625401-A | Non-sedating barbituric acid derivatives | TARO PHARMA IND (IL) | 2005-06-08 | — | — | CN | disclosed |
| EP-1485101-A1 | NON-SEDATING BARBITURIC ACID DERIVATIVES | Taro Pharmaceutical Industries Limited (IL) | 2004-12-15 | — | — | EP | disclosed |
| US-20030187005-A1 | Non-sedating barbituric acid derivatives | TARO PHARMACEUTICAL INDUSTRIES LTD. | 2003-10-02 | — | — | US | disclosed |
| WO-2003063872-A1 | NON-SEDATING BARBITURIC ACID DERIVATIVES | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132529-A1 | Method of improving bioavailability for non-sedating barbiturates | MTNR1B, GABRB3, GABBR1 | ELANE 3270/4885ALDH1A1 790/4885CYP1A2 299/4885 |
| US-20030187005-A1 | Non-sedating barbituric acid derivatives | GABRA5, GABRA1, GABRA3 | ELANE 846/4885ALDH1A1 283/4885CYP1A2 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.