Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430147 | 1.00 | RNPEP (0.46) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL474907 | 0.84 | ALDH1A1 (0.43) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL2106793 | 0.83 | RNPEP (0.47) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL14383421 | 0.83 | RNPEP (0.47) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL2106791 | 0.83 | RNPEP (0.47) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL8602261 | 0.81 | RNPEP (0.46) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL8602262 | 0.81 | RNPEP (0.46) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8760496 | 0.80 | LMNA (0.44) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8760503 | 0.80 | LMNA (0.44) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8396926 | 0.79 | LMNA (0.50) | RNPEPLMNASMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109091681-A | [18F]Trifluoromethyl sulfur-containing amino acid PET developer and preparation method and application thereof | 中山大学附属第医院 | 2018-12-28 | — | — | CN | claimed |
| US-20090326196-A1 | Proteins Containing a Fluorinated Amino Acid, and Methods of Using Same | TRUSTEES OF TUFTS COLLEGE | 2009-12-31 | — | — | US | claimed |
| EP-1993582-A2 | PROTEINS CONTAINING A FLUORINATED AMINO ACID, AND METHODS OF USING SAME | Trustees Of Tufts College (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007084527-A2 | PROTEINS CONTAINING A FLUORINATED AMINO ACID, AND METHODS OF USING SAME | TRUSTEES OF TUFTS COLLEGE (US) | 2007-07-26 | — | — | WO | claimed |
| CN-109091681-B | [18F]Trifluoromethyl sulfur-containing amino acid PET developer and preparation method and application thereof | 中山大学附属第一医院 | 2021-08-03 | — | — | CN | disclosed |
| CN-109091681-A | [18F]Trifluoromethyl sulfur-containing amino acid PET developer and preparation method and application thereof | 中山大学附属第医院 | 2018-12-28 | — | — | CN | disclosed |
| US-20090326196-A1 | Proteins Containing a Fluorinated Amino Acid, and Methods of Using Same | TRUSTEES OF TUFTS COLLEGE | 2009-12-31 | — | — | US | disclosed |
| EP-1993582-A2 | PROTEINS CONTAINING A FLUORINATED AMINO ACID, AND METHODS OF USING SAME | Trustees Of Tufts College (US) | 2008-11-26 | — | — | EP | disclosed |
| US-7371867-B2 | Non-racemic trifluoroleucine, and methods of making and using | TRUSTEES OF TUFTS COLLEGE (US) | 2008-05-13 | — | — | US | disclosed |
| WO-2007084527-A2 | PROTEINS CONTAINING A FLUORINATED AMINO ACID, AND METHODS OF USING SAME | TRUSTEES OF TUFTS COLLEGE (US) | 2007-07-26 | — | — | WO | disclosed |
| US-20070112200-A1 | Non-racemic hexafluoreleucine,and methods of making and using it | TRUSTEES OF TUFTS COLLEGE (US) | 2007-05-17 | — | — | US | disclosed |
| US-7132559-B2 | Non-racemic hexafluoroleucine, and methods of making and using it | TRUSTEES OF TUFTS COLLEGE (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040138493-A1 | Non-racemic hexafluoreleucine, and methods of making and using it | TRUSTEES OF TUFTS COLLEGE | 2004-07-15 | — | — | US | disclosed |
| WO-2002068592-A2 | NON-RACEMIC HEXAFLUORELEUCINE, AND METHODS OF MAKING AND USING IT | TRUSTEES OF TUFTS COLLEGE (US) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326196-A1 | Proteins Containing a Fluorinated Amino Acid, and Methods of Using Same | DNPEP, NPEPPS, ANPEP | RNPEP 15/4885LMNA 3685/4885SMN1; SMN2 1879/4885 |
| US-20070112200-A1 | Non-racemic hexafluoreleucine,and methods of making and using it | CRYZ, FABP5, FAU | RNPEP 260/4885LMNA 2293/4885SMN1; SMN2 2812/4885 |
| US-20040138493-A1 | Non-racemic hexafluoreleucine, and methods of making and using it | NPFFR1, FNTB, CRYZ | RNPEP 964/4885LMNA 2240/4885SMN1; SMN2 1272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.