SCHEMBL443047

SCHEMBL443047

CCc1cc(C)cc(-n2c(-c3ccccc3)c3ccccc3c2-c2ccccc2)c1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.38
RECQL P46063 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPT P10636 5/20 0.37
TP53 P04637 5/20 0.34
FFAR4 Q5NUL3 1/20 0.33
IL1R1 P14778 1/20 0.33
ALDH1A1 P00352 2/20 0.33
GRIK2 Q13002 1/20 0.33
MEN1 O00255 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HPGD P15428 1/20 0.33
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL443171 0.81 MGLL (0.45) POLBRECQLSMN1; SMN2MAPTTP53
SCHEMBL445312 0.79 TP53 (0.45) POLBRECQLSMN1; SMN2MAPTTP53
SCHEMBL442621 0.77 ALDH1A1 (0.40) MAPTALDH1A1KDM4EHPGD
SCHEMBL443111 0.76 GAA (0.51) POLBSMN1; SMN2MAPTTP53ALDH1A1
SCHEMBL26451206 0.74 RXRA (0.39) MAPTTP53L3MBTL1KDM4E
SCHEMBL445355 0.73 ALDH1A1 (0.48) SMN1; SMN2IL1R1ALDH1A1HTTKDM4E
SCHEMBL19267343 0.72 KDM4E (0.38) MAPTALDH1A1MEN1HTTKMT2A
SCHEMBL444948 0.70 CYP1A2 (0.42) RECQLSMN1; SMN2MAPTALDH1A1MEN1
SCHEMBL443170 0.70 KDM4E (0.52) POLBRECQLSMN1; SMN2MAPTIL1R1
SCHEMBL13815322 0.68 KDM4E (0.52) POLBRECQLMAPTTP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed