SCHEMBL445312

SCHEMBL445312

CCc1ccc(-n2c(-c3ccccc3)c3ccccc3c2-c2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 4/20 0.45
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
KDM4E B2RXH2 1/20 0.43
THRB P10828 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
POLB P06746 2/20 0.42
RECQL P46063 1/20 0.42
IL1R1 P14778 1/20 0.41
MAPT P10636 3/20 0.40
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CTSV O60911 1/20 0.39
CTSL P07711 1/20 0.39
FAAH O00519 1/20 0.38
APOBEC3G Q9HC16 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL443171 0.81 MGLL (0.45) TP53SMN1; SMN2POLBRECQLIL1R1
SCHEMBL443170 0.80 KDM4E (0.52) KDM4ESMN1; SMN2POLBRECQLIL1R1
SCHEMBL445355 0.79 ALDH1A1 (0.48) NPC1RAB9AKDM4ESMN1; SMN2IL1R1
SCHEMBL443047 0.79 POLB (0.38) TP53KDM4ETHRBSMN1; SMN2POLB
SCHEMBL443174 0.78 MAPT (0.60) TP53NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL442603 0.76 L3MBTL1 (0.41) TP53KDM4ETHRBSMN1; SMN2POLB
SCHEMBL10067476 0.76 KDM4E (0.59) TP53NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL443060 0.75 LMNA (0.57) RAB9AKDM4ESMN1; SMN2MAPTALDH1A1
SCHEMBL7100416 0.75 KDM4E (0.53) TP53NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL21085796 0.73 RXRA (0.45) TP53NPC1RAB9AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed