Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | CA6 | P23280 | 2/20 | 0.53 |
| ▸ | CA5A | P35218 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664501 | 0.78 | HCAR2 (0.57) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL3127108 | 0.78 | LMNA (0.46) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL10367878 | 0.77 | HCAR2 (0.61) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL219575 | 0.77 | HCAR2 (0.65) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL3664499 | 0.77 | HCAR2 (0.56) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL16631728 | 0.77 | ALDH1A1 (0.46) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL3664497 | 0.77 | HCAR2 (0.56) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL337503 | 0.76 | HCAR2 (0.89) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL9395526 | 0.76 | HCAR2 (0.69) | LMNAHCAR2ALDH1A1CA12CA4 | |
| SCHEMBL357565 | 0.76 | HCAR2 (0.89) | LMNAHCAR2ALDH1A1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130012466-A1 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-01-10 | — | — | US | disclosed |
| US-8232254-B2 | Colchicine glycosylated to include a sugar moiety on a methoxyamino-appended colchicine; cytolysis equivalent to paclitaxel and doxorubicin; stabilizers of tubulin formation; anticarcinogenic -arthritic agents; Mediterranean fever, amyloidosis, scleroderma, irritable bowel syndrome or gout | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2076525-A2 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | Wisconsin Alumni Research Foundation (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008067039-A9 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | WISCONSIN ALUMNI RES FOUND (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20080171787-A1 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-07-17 | — | — | US | disclosed |
| WO-2008067039-A2 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171787-A1 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | TUBB6, TUBB, TUBA1C | LMNA 1662/4885HCAR2 3353/4885ALDH1A1 3136/4885 |
| US-20130012466-A1 | COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE | TUBB6, TUBB, TUBA1C | LMNA 1662/4885HCAR2 3353/4885ALDH1A1 3136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.