Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5944261 | 0.84 | CYP19A1 (0.32) | — | |
| SCHEMBL2203810 | 0.77 | OPRM1 (0.40) | HTR2ABACE1NPSR1GPR55OPRM1 | |
| SCHEMBL654291 | 0.77 | HTR2A (0.47) | HTR2ABACE1NPSR1GPR55OPRM1 | |
| SCHEMBL4436585 | 0.74 | HTR2A (0.44) | HTR2ABACE1OPRM1MAOACACNA1F | |
| SCHEMBL1254663 | 0.74 | HTR2A (0.44) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL10682672 | 0.74 | HTR2A (0.44) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL1255254 | 0.74 | HTR2A (0.41) | HTR2ANPSR1GPR55OPRM1CACNA1F | |
| SCHEMBL6361063 | 0.71 | HTR2A (0.39) | HTR2AOPRM1KDM1AMAOAKCNH2 | |
| SCHEMBL4722907 | 0.70 | OPRM1 (0.38) | HTR2AOPRM1OPRK1OPRL1 | |
| SCHEMBL2486825 | 0.70 | BACE1 (0.38) | HTR2ABACE1NPSR1GPR55MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | claimed |
| EP-2558449-B1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-05 | — | — | EP | claimed |
| EP-2668165-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-04 | — | — | EP | claimed |
| US-8586747-B2 | 3,3-dimethyl tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-11-19 | — | — | US | claimed |
| EP-2558449-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | claimed |
| US-20130023518-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | Hoffmann-La Roche Inc (US) | 2013-01-24 | — | — | US | claimed |
| US-8344137-B2 | 3,3-dimethyl tetrahydroquinoline derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-01-01 | — | — | US | claimed |
| WO-2012101068-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-02 | — | — | WO | claimed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | claimed |
| US-20110257151-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | HUA MEDICINE (KY) | 2011-10-20 | — | — | US | claimed |
| US-7439238-B2 | Antiparasitic artemisinin derivatives (endoperoxides) | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2008-10-21 | — | — | US | claimed |
| US-20070191354-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-01-25 | — | — | US | claimed |
| EP-1095042-B9 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2006-07-05 | — | — | EP | claimed |
| EP-1655302-A2 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | claimed |
| EP-1095042-B1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | claimed |
| EP-1095042-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer Aktiengesellschaft (DE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000004024-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | claimed |
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |
| US-4107437-A | SEDATIVES, ANTIARRHYTHMIA AGENTS | PARCOR (FR) | 1978-08-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | RAB1A, RABL3, RAB7A | HTR2A 1107/4885BACE1 2896/4885NPSR1 766/4885 |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | HTR2A 3418/4885BACE1 3516/4885NPSR1 2565/4885 |
| US-20070191354-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | HTR2A 3418/4885BACE1 3516/4885NPSR1 2565/4885 |
| US-20110257151-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | QDPR, PRMT3, PRMT1 | HTR2A 402/4885BACE1 2662/4885NPSR1 853/4885 |
| US-20130023518-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | QDPR, PRMT3, PRMT1 | HTR2A 402/4885BACE1 2662/4885NPSR1 853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.