Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | IL6 | P05231 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | MAX | P61244 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445384 | 0.76 | HDAC4 (0.40) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL7570645 | 0.74 | HDAC4 (0.43) | HDAC4PDE7AHSD11B1 | |
| SCHEMBL7564524 | 0.73 | PSEN1 (0.43) | HDAC4PDE7AHSD11B1 | |
| SCHEMBL7571494 | 0.71 | P2RX7 (0.35) | HDAC4 | |
| SCHEMBL983451 | 0.70 | HDAC4 (0.49) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL4555611 | 0.70 | HDAC4 (0.45) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL4435176 | 0.70 | MEN1 (0.36) | HDAC4MEN1KMT2A | |
| SCHEMBL6260698 | 0.68 | SIGMAR1 (0.40) | HDAC6HDAC3HDAC1HDAC2KMT2A | |
| SCHEMBL30482361 | 0.66 | HDAC4 (0.47) | HDAC4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL2695956 | 0.66 | HDAC4 (0.47) | HDAC4HDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |