Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438513 | 0.91 | KDM4E (0.47) | SLC6A3SLC6A4KDM4EGLAGAA | |
| SCHEMBL4430819 | 0.86 | BRS3 (0.46) | SLC6A3SLC6A4KDM4ELIPGPTGDR2 | |
| SCHEMBL4431012 | 0.85 | SLC6A3 (0.58) | SLC6A3SLC6A4KDM4EGLAGAA | |
| SCHEMBL4439655 | 0.81 | MAPK8 (0.45) | KDM4EGLAGAAPDE3BPDE3A | |
| SCHEMBL3913842 | 0.80 | KDM4E (0.51) | SLC6A3SLC6A4KDM4EGLAGAA | |
| SCHEMBL4431808 | 0.79 | KDM4E (0.50) | KDM4EGLAGAAPDE3BPDE3A | |
| SCHEMBL4426834 | 0.78 | ALDH1A1 (0.54) | KDM4EGLAGAAPDE3BPDE3A | |
| SCHEMBL4433888 | 0.76 | KDM4E (0.53) | KDM4EGAASMN1; SMN2ALDH1A1BRS3 | |
| SCHEMBL4432962 | 0.76 | MDM2 (0.42) | KDM4EGAAPDE3BPDE3ANPC1 | |
| SCHEMBL4426842 | 0.76 | KDM4E (0.49) | SLC6A3SLC6A4KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |