Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438513 | 0.84 | KDM4E (0.47) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4431012 | 0.82 | SLC6A3 (0.58) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4437699 | 0.81 | SLC6A3 (0.55) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4431808 | 0.80 | KDM4E (0.50) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4426834 | 0.79 | ALDH1A1 (0.54) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL5154097 | 0.76 | KDM4E (0.54) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL10010690 | 0.74 | SLC6A3 (0.58) | MAPK8MAPK9MAPK10KDM4EGAA | |
| SCHEMBL4428291 | 0.73 | KDM4E (0.48) | MAPK8MAPK10KDM4EGAAGLA | |
| SCHEMBL4438837 | 0.73 | ALDH1A1 (0.49) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4433040 | 0.72 | MDM2 (0.41) | KDM4EGAAPDE3BPDE3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |