Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyltestosterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 3/20 | 0.72 |
| ▸ | SHBG | P04278 | 9/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 5/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 8/20 | 0.74 |
| ▸ | SERPINA6 | P08185 | 7/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | BLM | P54132 | 4/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 5/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyltestosterone SCHEMBL29416593 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL18657 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL6472960 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL5021655 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL18891626 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL13575766 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL13965283 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL13768123 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL6152059 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL4575985 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55049397-A | — | — | None | — | — | JP | disclosed |
| JP-55049396-A | — | — | None | — | — | JP | disclosed |
| US-20210199646-A1 | SAMPLE DEPLETION AND ENRICHMENT TO IMPROVE THE QUALITY OF DIAGNOSTIC TEST RESULTS | VERAVAS, INC. | 2021-07-01 | — | — | US | disclosed |
| US-10948484-B2 | Sample depletion and enrichment to improve the quality of diagnostic test results | VERAVAS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190137484-A9 | Sample depletion and enrichment to improve the quality of diagnostic test results | VERAVAS, INC. (US) | 2019-05-09 | — | — | US | disclosed |
| US-20180292394-A1 | Sample depletion and enrichment to improve the quality of diagnostic test results | SOLDO JOSHUA CAINE (US) | 2018-10-11 | — | — | US | disclosed |
| EP-2069790-B1 | BINDING SURFACES FOR AFFINITY ASSAYS | BECKMAN COULTER INC (US) | 2015-04-29 | — | — | EP | disclosed |
| US-8518714-B2 | Binding surfaces for affinity assays | BECKMAN COULTER, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2069790-A2 | BINDING SURFACES FOR AFFINITY ASSAYS | Beckman Coulter, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| US-7422854-B1 | Cholesterol reduction signature | ENTELOS, INC. (US) | 2008-09-09 | — | — | US | disclosed |
| EP-0288532-A1 | A METHOD FOR THE PREVENTION OF OCULAR HYPERTENSION, TREATMENT OF GLAUCOMA AND TREATMENT OF OCULAR HYPERTENSION | KNEPPER, Paul A. (US) | 1988-11-02 | — | — | EP | disclosed |
| WO-1988002628-A1 | A METHOD FOR THE PREVENTION OF OCULAR HYPERTENSION, TREATMENT OF GLAUCOMA AND TREATMENT OF OCULAR HYPERTENSION | KNEPPER PAUL A (US) | 1988-04-21 | — | — | WO | disclosed |
| US-4617299-A | ADMINISTERING SELECTED ANABOLIC ANDROGENIC COMPOUNDS | KNEPPER PAUL A (US) | 1986-10-14 | — | — | US | disclosed |
| EP-0054810-B1 | PROCESS FOR THE PREPARATION OF 3-OXO-DELTA-1,4-STEROIDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-07-30 | — | — | EP | disclosed |
| US-4383992-A | Water-soluble steroid compounds | LIPARI JOHN M | 1983-05-17 | — | — | US | disclosed |
| EP-0054810-A2 | Process for the preparation of 3-oxo-delta-1,4-steroids | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4322349-A | Process for preparing 6-methylene steroids | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-03-30 | — | — | US | disclosed |
| JP-S5549396-A | PREPARATION OF 17ALPHA-METHYLSTEROID | HOKKO CHEM IND CO LTD | 1980-04-09 | — | — | JP | disclosed |
| JP-S5549397-A | PREPARATION OF 17ALPHA-METHYLSTEROID | HOKKO CHEM IND CO LTD | 1980-04-09 | — | — | JP | disclosed |
| US-4160027-A | OXYTOCICS, 4A,5A-EPOXY-2A-CYANO-3-OXOSTEROIDES, STEROIDO(2,3-O)ISOOXAZOLES | STERLING DRUG INC. (US) | 1979-07-03 | — | — | US | disclosed |