Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyltestosterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 3/20 | 0.72 |
| ▸ | SHBG | P04278 | 9/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 5/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 8/20 | 0.74 |
| ▸ | SERPINA6 | P08185 | 7/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | BLM | P54132 | 4/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 5/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyltestosterone SCHEMBL29416593 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL13575766 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL13965283 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL13768123 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL4442874 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL6472960 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL18657 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL18891626 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL5021655 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A | |
| Methyltestosterone SCHEMBL6152059 | 1.00 | SHBG (1.00) | SHBGNR3C1PGRALDH1A1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030119796-A1 | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women | SCHERING CORPORATION | 2003-06-26 | — | — | US | claimed |
| CN-1026001-C | New esters of alginic acid | FIDIA SPA (IT) | 1994-09-28 | — | — | CN | claimed |
| CN-87104499-A | Novel alginic acid esters | — | 1988-04-06 | — | — | CN | claimed |
| CN-118006798-A | Preparation method and application of all-female grass carp parent | 中国科学院水生生物研究所 | 2024-05-10 | — | — | CN | disclosed |
| CN-116429952-B | Depression marker, application thereof in depression diagnosis and evaluation device | 深圳市第二人民医院(深圳市转化医学研究院) | 2024-02-02 | — | — | CN | disclosed |
| US-20230242984-A1 | SEX DETERMINATION MARKERS IN MULLETS AND METHODS OF USING THEREOF | THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI INSTITUTE] (IL) | 2023-08-03 | — | — | US | disclosed |
| CN-116429952-A | Depression marker, application thereof in depression diagnosis and evaluation device | 深圳市第二人民医院(深圳市转化医学研究院) | 2023-07-14 | — | — | CN | disclosed |
| CN-116347978-A | Sex determination markers in mullet and methods of use thereof | 以色列国家农业部·农村发展农业研究组织·沃尔卡尼机构 | 2023-06-27 | — | — | CN | disclosed |
| US-11541062-B2 | Methods of treating advanced prostate cancer | CITY OF HOPE (US) | 2023-01-03 | — | — | US | disclosed |
| US-11536733-B2 | Methods and systems for the detection of 11-oxo androgens by LC-MS/MS | LABORATORY CORPORATION OF AMERICA HOLDINGS (US) | 2022-12-27 | — | — | US | disclosed |
| US-20200333361-A1 | Methods and Systems for the Detection of 11-Oxo Androgens by LC-MS/MS | LABORATORY CORPORATION OF AMERICA HOLDINGS | 2020-10-22 | — | — | US | disclosed |
| CN-104230031-A | Method for extracting multicomponent drugs and personal care products in surface water | RES CT ECO ENVIRONMENTAL SCIEN | 2014-12-24 | — | — | CN | disclosed |
| US-7422854-B1 | Cholesterol reduction signature | ENTELOS, INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20060199793-A1 | Sterol absorption inhibitor compounds | CHO WING-KEE P | 2006-09-07 | — | — | US | disclosed |
| CN-1026001-C | New esters of alginic acid | FIDIA SPA (IT) | 1994-09-28 | — | — | CN | disclosed |
| CN-1092287-A | Discharge and its implementation with variable dose rate control medicine percutaneous | UNIV RUTGERS (US) | 1994-09-21 | — | — | CN | disclosed |
| CN-1025035-C | Cross-linked esters of hyaluronic acid | FIDIA SPA (IT) | 1994-06-15 | — | — | CN | disclosed |
| CN-87106919-A | CROSS-LINKED ESTERS OF HYALURONIC ACID | — | 1988-08-24 | — | — | CN | disclosed |
| CN-87104499-A | Novel alginic acid esters | — | 1988-04-06 | — | — | CN | disclosed |
| US-4160027-A | OXYTOCICS, 4A,5A-EPOXY-2A-CYANO-3-OXOSTEROIDES, STEROIDO(2,3-O)ISOOXAZOLES | STERLING DRUG INC. (US) | 1979-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119796-A1 | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women | SHBG, CYP46A1, HSD3B1 | AR 914/4885SHBG 1/4885NR3C1 334/4885 |
| US-20060199793-A1 | Sterol absorption inhibitor compounds | SREBF1, CYP46A1, FABP2 | AR 531/4885SHBG 61/4885NR3C1 675/4885 |
| US-11541062-B2 | Methods of treating advanced prostate cancer | KLK3, AR, ACP3 | AR 2/4885SHBG 4/4885NR3C1 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.