Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 4/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.52 |
| ▸ | PRKACA | P17612 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31507470 | 0.84 | CDC7 (0.65) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL5618155 | 0.80 | TGFBR1 (0.71) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL857504 | 0.77 | CDK2 (0.52) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL1050911 | 0.75 | TGFBR1 (0.60) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL16719379 | 0.73 | TGFBR1 (0.57) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL3740263 | 0.73 | CAMKK2 (0.69) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL857182 | 0.72 | TGFBR1 (0.57) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL10395104 | 0.72 | CDC7 (0.70) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL4827398 | 0.72 | CDC7 (0.53) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL15436437 | 0.72 | CDK9 (0.53) | CDC7MAP4K4PIM1PRKACAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306126-A1 | Indole Derivatives | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306126-A1 | Indole Derivatives | MTOR, IDO1, AKT1S1 | CDC7 1393/4885MAP4K4 465/4885PIM1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.