Sugi Predict

Sugi Predict / Compounds / SCHEMBL444686

SCHEMBL444686

SCHEMBL444686

Nc1ccc(Cl)c(CO)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 3/20 0.52
▸ TSHR P16473 3/20 0.52
▸ CA1 P00915 2/20 0.46
▸ CA2 P00918 2/20 0.46
▸ ALDH1A1 P00352 4/20 0.41
▸ THRB P10828 2/20 0.41
▸ HPGD P15428 1/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ CASP1 P29466 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ HTR2A P28223 1/20 0.39
▸ SLC6A4 P31645 1/20 0.39
▸ PRKCI P41743 1/20 0.38
▸ ACHE P22303 2/20 0.37
▸ CA12 O43570 1/20 0.37
▸ CA7 P43166 1/20 0.37
▸ CA9 Q16790 1/20 0.37
▸ CA14 Q9ULX7 1/20 0.37
▸ MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4510171 0.83 CYP3A4 (0.48) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL4015310 0.82 CYP3A4 (0.52) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL14907879 0.79 CYP3A4 (0.54) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL13183889 0.78 PRKCI (0.42) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL282088 0.77 CYP3A4 (0.52) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL2665541 0.77 CYP3A4 (0.52) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL29437148 0.76 PRKCI (0.41) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL92968 0.76 CYP3A4 (0.48) CYP3A4TSHRALDH1A1HPGDALOX15
SCHEMBL33604 0.76 PRKCI (0.41) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL15471848 0.75 TAAR1 (0.62) ALDH1A1ALOX15RECQLHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486115-B1 ELECTRORHEOLOGIC FLUID COMPRISING ORGANIC SUBSTANCES THAT CAN BE DOPED AND USE THEREOF FRAUNHOFER GES FORSCHUNG (DE) 2015-05-20 — — EP claimed
US-20250346567-A1 SUBSTITUTED PYRIDINE AND PHENYL COMPOUNDS PFIZER INC. (US) 2025-11-13 — — US disclosed
US-12180249-B1 Compositions and methods for selective labeling of secondary amines EMORY UNIVERSITY (US) 2024-12-31 — — US disclosed
US-20220081737-A1 POND REACTOR FOR RECOVERY OF METALS CYCAD GROUP, LLC 2022-03-17 — — US disclosed
US-20210340025-A1 Compositions and Methods for Purification of Metals from Steel Making Waste Streams CYCAD GROUP, LLC 2021-11-04 — — US disclosed
EP-3853177-A1 COMPOSITIONS AND METHODS FOR PURIFICATION OF METALS FROM STEEL MAKING WASTE STREAMS Lixivia, Inc. (US) 2021-07-28 — — EP disclosed
CN-113165897-A Compositions and methods for purifying metals from steelmaking waste streams 里克希维亚有限公司 2021-07-23 — — CN disclosed
WO-2020131958-A1 POND REACTOR FOR RECOVERY OF METALS Lixivia, Inc. (US) 2020-06-25 — — WO disclosed
US-10160748-B2 Indazolones as modulators of tnf signaling ABBVIE INC. (US) 2018-12-25 — — US disclosed
US-20180223392-A1 COMPOSITIONS AND METHODS FOR RECOVERY OF ALKALINE METALS CYCAD GROUP, LLC 2018-08-09 — — US disclosed
CN-1344270-A Functionalized heterocycles as chemokine receptor modulators THOUSAND YEARS MEDICAMENTS INC (US) 2002-04-10 — — CN disclosed
EP-1144415-A2 FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS WARNER-LAMBERT COMPANY (US) 2001-10-17 — — EP disclosed
WO-2000042045-A2 FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS WARNER-LAMBERT COMPANY (US) 2000-07-20 — — WO disclosed
US-5446178-A Cyclization of precursor steroid compound SCHERING AKTIENGESELLSCHAFT (DE) 1995-08-29 — — US disclosed
US-5095129-A Antiglucocorticoid, antimineralcorticoid, antiandrogen SCHERING AKTIENGESELLSCHAFT (DE) 1992-03-10 — — US disclosed
EP-0283428-B1 19,11-BETA-BRIDGED STEROIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING AKTIENGESELLSCHAFT (DE) 1991-10-30 — — EP disclosed
EP-0289910-A2 Substituted tetrahydrophthalimides, process for their preparation and their use as herbicides HOECHST AKTIENGESELLSCHAFT (DE) 1988-11-09 — — EP disclosed
WO-1988007051-A1 19, 11beta-BRIDGED STEROIDS, THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) 1988-09-22 — — WO disclosed
EP-0283428-A1 19,11-Beta-bridged steroids, their preparation and pharmaceutical compositions containing them SCHERING AKTIENGESELLSCHAFT (DE) 1988-09-21 — — EP disclosed
WO-1987007602-A2 N-(5-SUBSTITUTED METHYLENE) PHENYL HERBICIDES RHONE-POULENC AGROCHIMIE (FR) 1987-12-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250346567-A1 SUBSTITUTED PYRIDINE AND PHENYL COMPOUNDS PAH, PC, MPC2 CYP3A4 259/4885TSHR 3602/4885CA1 4770/4885
US-12180249-B1 Compositions and methods for selective labeling of secondary amines ADAR, RNMT, ALKBH1 CYP3A4 4434/4885TSHR 1284/4885CA1 2332/4885
US-10160748-B2 Indazolones as modulators of tnf signaling TNF, CD40, TNFRSF1A CYP3A4 376/4885TSHR 1871/4885CA1 4841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.