SCHEMBL444700

SCHEMBL444700

C=C(CCCc1ccc(Cc2ccccc2)cc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 6/20 0.56
HDAC3 O15379 3/20 0.56
HDAC2 Q92769 3/20 0.56
HDAC8 Q9BY41 3/20 0.56
HDAC6 Q9UBN7 3/20 0.56
HDAC5 Q9UQL6 3/20 0.56
HDAC4 P56524 2/20 0.56
HDAC7 Q8WUI4 2/20 0.56
HDAC10 Q969S8 2/20 0.56
HDAC11 Q96DB2 2/20 0.56
HDAC9 Q9UKV0 2/20 0.56
MAPK1 P28482 1/20 0.56
ADRA1A P35348 1/20 0.56
SLC6A3 Q01959 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
NPC1 O15118 1/20 0.51
CASP3 P42574 1/20 0.51
RAB9A P51151 1/20 0.51
SENP8 Q96LD8 1/20 0.51
SENP7 Q9BQF6 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17940810 0.93 HDAC1 (0.60) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL114130 0.93 HDAC1 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL4666437 0.93 HDAC1 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
Hydrochloric Acid SCHEMBL11273048 0.91 HDAC1 (0.62) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL1920994 0.89 FFAR1 (0.55) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL443150 0.87 MAPT (0.63) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL1920267 0.86 FFAR1 (0.58) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL8971314 0.86 MAPT (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL6666636 0.86 MAPT (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL626409 0.86 MAPT (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121802-B1 HIGH REFRACTIVE INDEX SILOXANE INSERT MATERIALS FOR EMBEDDED CONTACT LENSES ALCON INC (CH) 2024-07-17 EP claimed
EP-3728339-B1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS AMO Ireland (IE) 2022-07-06 EP claimed
EP-2303331-B1 OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME ALCON INC (CH) 2022-01-26 EP claimed
EP-3200840-B1 LOW-WATER CONTENT ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES ALCON INC (CH) 2021-11-17 EP claimed
US-10756139-B2 Organic light emitting display SAMSUNG SDI CO., LTD. (KR) 2020-08-25 US claimed
US-10727443-B2 Organic light emitting display SAMSUNG SDI CO., LTD. (KR) 2020-07-28 US claimed
US-10570220-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same SAMSUNG SDI CO., LTD. (KR) 2020-02-25 US claimed
EP-3200839-B1 HYDROPHOBIC ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES NOVARTIS AG (CH) 2019-09-04 EP claimed
US-10316112-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same SAMSUNG SDI CO., LTD. (KR) 2019-06-11 US claimed
EP-3223870-B1 WET-PACK INTRAOCULAR LENS MATERIALS WITH HIGH REFRACTIVE INDEX NOVARTIS AG (CH) 2018-09-26 EP claimed
US-20110281995-A1 Polycarbonate Resin Composition and Molded Product Using the Same CHEIL INDUSTRIES INC. (KR) 2011-11-17 US claimed
EP-2341102-A1 Thermoplastic resin composition revealing improved impact strength and melt flow property Cheil Industries Inc. (KR) 2011-07-06 EP claimed
US-20110160377-A1 Thermoplastic Resin Composition Having Improved Impact Strength and Melt Flow Properties CHEIL INDUSTRIES INC. (KR) 2011-06-30 US claimed
EP-2225325-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2011-06-01 EP claimed
US-20100160559-A1 Polylactic Acid/Polycarbonate Resin Composition and Molded Product Made Using the Same CHEIL INDUSTRIES INC. (KR) 2010-06-24 US claimed
EP-2199342-A2 Polylactic acid/polycarbonate resin composition and molded product made using the same Cheil Industries Inc. (KR) 2010-06-23 EP claimed
EP-1080382-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2009-07-08 EP claimed
EP-1664855-B1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB (US) 2009-03-11 EP claimed
EP-1177227-B1 WATER PLASTICIZED HIGH REFRACTIVE INDEX POLYMER FOR OPHTHALMIC APPLICATIONS SURGIDEV CORP (US) 2003-10-01 EP claimed
EP-0914169-B1 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LAB INC (US) 2003-07-30 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10316112-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same ICAM1, CD40LG, VCAM1 HDAC1 4203/4885HDAC3 4868/4885HDAC2 4307/4885
US-10570220-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same TRPA1, ALKBH1, AHCYL1 HDAC1 4266/4885HDAC3 4868/4885HDAC2 4371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.