⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810741 | 0.76 | — | — | |
| SCHEMBL2076291 | 0.70 | TDP1 (0.33) | — | |
| SCHEMBL17491822 | 0.67 | — | — | |
| SCHEMBL20985453 | 0.67 | LMNA (0.35) | — | |
| SCHEMBL2686579 | 0.65 | — | — | |
| SCHEMBL1663096 | 0.63 | — | — | |
| SCHEMBL5806133 | 0.62 | PRKCA (0.32) | — | |
| SCHEMBL7810060 | 0.62 | THRB (0.32) | — | |
| SCHEMBL16797539 | 0.60 | — | — | |
| SCHEMBL9174410 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487533-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| EP-2114950-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2016-03-09 | — | — | EP | disclosed |
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| US-20080269210-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-30 | — | — | US | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| US-5214139-A | 2-phenanthridonyl-carbapenems | MERCK & CO., INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5208328-A | Intermediates for antibiotics and bactericides | MERCK & CO., INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0509780-A1 | 2-phenanthridonyl carbapenems | MERCK & CO. INC. (US) | 1992-10-21 | — | — | EP | disclosed |
| EP-0509756-A1 | 2-Phenanthridonyl carbapenems having cationizeable substituents | MERCK & CO. INC. (US) | 1992-10-21 | — | — | EP | disclosed |
| US-5157033-A | Controlling methicillin-resistant grampositive Staphylococcus; bactericides | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5153185-A | Antibiotics for methicillin resistant Staphylococcus strains | MERCK & CO., INC. (US) | 1992-10-06 | — | — | US | disclosed |