SCHEMBL444779

SCHEMBL444779

CCOc1cccc(-n2c(-c3ccccc3)c3ccccc3c2-c2ccccc2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.49
TP53 P04637 2/20 0.49
NOTUM Q6P988 1/20 0.49
HPGD P15428 2/20 0.48
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
CYP3A4 P08684 1/20 0.44
MAPT P10636 5/20 0.43
TTK P33981 1/20 0.43
NPSR1 Q6W5P4 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
MEN1 O00255 1/20 0.42
ALOX12 P18054 1/20 0.42
KMT2A Q03164 1/20 0.42
LMNA P02545 1/20 0.42
RAB9A P51151 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LTA4H P09960 1/20 0.42
USP2 O75604 1/20 0.41
FAAH O00519 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL443174 0.84 MAPT (0.60) SMN1; SMN2TP53HPGDMAPTNPSR1
SCHEMBL443120 0.83 SMN1; SMN2 (0.56) SMN1; SMN2NOTUMHPGDCYP3A4MAPT
SCHEMBL443171 0.78 MGLL (0.45) SMN1; SMN2TP53MAPTMEN1KMT2A
SCHEMBL443111 0.76 GAA (0.51) SMN1; SMN2TP53NOTUMHPGDMAPT
SCHEMBL30338775 0.75 RXRA (0.70) SMN1; SMN2TP53NOTUMRXRARXRB
SCHEMBL203120 0.75 RXRA (0.70) SMN1; SMN2TP53NOTUMRXRARXRB
SCHEMBL443170 0.74 KDM4E (0.52) SMN1; SMN2HPGDMAPTMEN1KMT2A
SCHEMBL29587729 0.73 SMN1; SMN2 (0.62) SMN1; SMN2TP53HPGDRXRARXRB
SCHEMBL445320 0.73 SMN1; SMN2 (0.52) SMN1; SMN2NOTUMCYP3A4MAPTNPSR1
SCHEMBL602200 0.73 SMN1; SMN2 (0.62) SMN1; SMN2TP53HPGDRXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed