Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9420879 | 0.87 | PTGS1 (0.69) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Cicloprofen SCHEMBL30578072 | 0.82 | PTGS2 (0.56) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Cicloprofen SCHEMBL42839 | 0.82 | PTGS2 (0.56) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL10844042 | 0.80 | ABCC4 (0.43) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL12726876 | 0.79 | AKR1B1 (0.54) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL11477693 | 0.79 | PTGS1 (0.58) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| SCHEMBL11339446 | 0.79 | PTGS2 (0.54) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Pranoprofen SCHEMBL5936565 | 0.78 | PTGS1 (1.00) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Pranoprofen SCHEMBL30509656 | 0.78 | PTGS1 (1.00) | PTGS1ABCC4PTGS2OPRK1PDE4D | |
| Pranoprofen SCHEMBL26008 | 0.78 | PTGS1 (1.00) | PTGS1ABCC4PTGS2OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |