Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14680363 | 0.81 | SMN1; SMN2 (0.47) | MGLLKMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4449468 | 0.79 | POLB (0.46) | MGLLKMT2AHPGDALDH1A1CA1 | |
| SCHEMBL4733762 | 0.79 | MAPT (0.49) | KMT2ATP53HPGDALDH1A1MEN1 | |
| SCHEMBL14067636 | 0.79 | ALDH1A1 (0.40) | MGLLKMT2AHPGDALDH1A1HTT | |
| SCHEMBL11616115 | 0.73 | ABL1 (0.57) | KMT2AHPGDALDH1A1HTTMEN1 | |
| SCHEMBL7854466 | 0.73 | MGLL (0.50) | MGLLKMT2AHPGDALDH1A1CA1 | |
| SCHEMBL1284517 | 0.72 | TSHR (0.48) | KMT2AALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL31225704 | 0.71 | KMT2A (0.57) | KMT2AHPGDALDH1A1HTTMEN1 | |
| SCHEMBL6018300 | 0.70 | HTR3E (0.41) | MGLLKMT2AHPGDALDH1A1HTT | |
| SCHEMBL4752381 | 0.70 | MGLL (0.47) | MGLLKMT2AHPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425262-B1 | Acylthiols and compositions thereof as anti-HIV and anti-retroviral agents | GOV OF USA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES NAT INST OF HEALTH (US) | 2014-01-08 | — | — | EP | disclosed |
| US-8076372-B2 | Acythiols and component thiol compositions as anti-HIV and anti-retroviral agents | GOVERNMENT OF THE UNITED STATES (US) | 2011-12-13 | — | — | US | disclosed |
| US-20090247473-A1 | ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | THE GOVERNMENT OF THE U.S.A.,AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2009-10-01 | — | — | US | disclosed |
| US-7528274-B2 | Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-05-05 | — | — | US | disclosed |
| EP-1425262-A4 | ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | US GOV HEALTH & HUMAN SERV (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20050020831-A1 | Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents | GOVERNMENT OF THE UNITED STATES | 2005-01-27 | — | — | US | disclosed |
| EP-1425262-A1 | ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | The Gov. of USA, as represented by the Secretary, Dept. of Health and Human services, National Institutes of Health (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003014062-A1 | ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247473-A1 | ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | ZC3HAV1, ZFP3, ATL3 | MGLL 3500/4885KMT2A 1401/4885TP53 1134/4885 |
| US-20050020831-A1 | Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents | ZC3HAV1, ACAT2, ACAT1 | MGLL 1866/4885KMT2A 1222/4885TP53 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.