Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.50 |
| ▸ | TUBB | P07437 | 4/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452966 | 1.00 | HPGD (0.56) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL27764517 | 0.81 | TUBB4A (0.57) | HPGDSMN1; SMN2ALDH1A1TUBB4ATUBB | |
| SCHEMBL27955374 | 0.81 | HPGD (0.54) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL3471747 | 0.81 | HPGD (0.59) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL7145109 | 0.81 | AMY1A (0.54) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL15463039 | 0.81 | HPGD (0.59) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL3471744 | 0.81 | HPGD (0.59) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL25322838 | 0.79 | AMY1A (0.53) | HPGDAMY1ASMN1; SMN2ALDH1A1CYP1A1 | |
| SCHEMBL9601347 | 0.77 | ALDH1A1 (0.59) | HPGDSMN1; SMN2ALDH1A1CYP1A1CYP1A2 | |
| SCHEMBL9601338 | 0.77 | ALDH1A1 (0.59) | HPGDSMN1; SMN2ALDH1A1CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050452-A1 | indenoisoquinolines as topoisomerase inhibitors I useful as antineoplastic agents | Purdue Research Foundation (US) | 2009-04-22 | — | — | EP | disclosed |
| US-6509344-B1 | A method for treating a patient having cancer, said method comprising the step of administering to the patient an effective amount of a compound according to claim 1, whereupon said patient is treated for cancer, and wherein the cancer is | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-01-21 | — | — | US | disclosed |
| EP-1123099-A4 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1123099-A1 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000021537-A1 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2000-04-20 | — | — | WO | disclosed |