Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NEK2 | P51955 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14515118 | 0.80 | OPRM1 (0.41) | KDM4EALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL8557410 | 0.72 | L3MBTL1 (0.51) | KDM4EALDH1A1HSD17B10L3MBTL1MAPT | |
| SCHEMBL17262676 | 0.72 | KDM4E (0.44) | KDM4EKMT2AMAPTTHRBCYP2C19 | |
| SCHEMBL15769958 | 0.71 | NEK2 (0.51) | KDM4ENEK2ALDH1A1KMT2AMEN1 | |
| SCHEMBL25273521 | 0.71 | PPARG (0.42) | KDM4EHSD17B10ACKR3SMN1; SMN2 | |
| SCHEMBL13003360 | 0.71 | L3MBTL1 (0.50) | KDM4ENEK2L3MBTL1 | |
| SCHEMBL3297456 | 0.70 | L3MBTL1 (0.49) | KDM4ENEK2L3MBTL1 | |
| SCHEMBL493277 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL14515115 | 0.67 | LTA4H (0.52) | KDM4EALDH1A1KMT2AHSD17B10CYP2C19 | |
| SCHEMBL8558345 | 0.66 | KDM4E (0.40) | KDM4ENEK2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755974-A1 | NEW ENZYME INHIBITOR COMPOUNDS | Proximagen Limited (GB) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013037411-A1 | NEW ENZYME INHIBITOR COMPOUNDS | PROXIMAGEN LIMITED (GB) | 2013-03-21 | — | — | WO | disclosed |
| EP-2136805-A2 | PIPERIDINYL-PIPERIDINE AND PIPERAZINYL-PIPERIDINE FOR USE IN THE TREATMENT OF DIABETES OR PAIN | SCHERING CORPORATION (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008108957-A2 | PIPERIDINYL-PIPERIDINE AND PIPERAZINYL-PIPERIDINE FOR USE IN THE TREATMENT OF DIABETES OR PAIN | SCHERING CORPORATION (US) | 2008-09-12 | — | — | WO | disclosed |