Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 6/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 6/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 6/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27801909 | 0.77 | PTGS2 (0.44) | MAPK1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL18240475 | 0.73 | — | — | |
| SCHEMBL27685077 | 0.70 | SMN1; SMN2 (0.43) | CASP3SENP8SENP7SENP6LMNA | |
| Alcohol SCHEMBL20553646 | 0.70 | ALDH1A1 (0.59) | MAPK1LMNATSHRHPGDRAB9A | |
| SCHEMBL980892 | 0.67 | GABRA1 (0.50) | LMNATSHRHPGDCYP2D6ALDH1A1 | |
| SCHEMBL29362539 | 0.67 | GABRA1 (0.50) | LMNATSHRHPGDCYP2D6ALDH1A1 | |
| SCHEMBL28574 | 0.67 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6LMNA | |
| SCHEMBL30442890 | 0.67 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6LMNA | |
| SCHEMBL29623192 | 0.67 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6LMNA | |
| SCHEMBL27659427 | 0.67 | ALDH1A1 (0.67) | CASP3SENP8SENP7SENP6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GILLESPIE PAUL | 2009-06-18 | — | — | US | disclosed |
| US-7524870-B2 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | HOFFMANN-LA ROCHE INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20060122256-A1 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | GILLESPIE PAUL | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, GYS1, GSK3A | CASP3 2344/4885SENP8 4520/4885SENP7 4417/4885 |
| US-20060122256-A1 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | GYS2, GYS1, GSK3A | CASP3 2344/4885SENP8 4520/4885SENP7 4417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.