Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 9/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALAD | P13716 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196775 | 0.77 | CYP1A2 (0.44) | HSD17B1HSD17B2ESR2MEN1KMT2A | |
| SCHEMBL3141614 | 0.75 | CYP3A4 (0.61) | HSD17B1HSD17B2ESR2CYP3A4CYP2C9 | |
| SCHEMBL19567240 | 0.74 | POLB (0.44) | ALADNPC1TP53MAPTRAB9A | |
| SCHEMBL17715302 | 0.74 | RAB9A (0.46) | ESR2ABL1ABCB1BCRMEN1 | |
| SCHEMBL28196743 | 0.71 | HSD17B1 (0.47) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL6450949 | 0.69 | ALAD (0.71) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL15632 | 0.69 | ESR1 (1.00) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL6292004 | 0.69 | ESR1 (1.00) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL30826784 | 0.69 | ESR1 (1.00) | HSD17B1HSD17B2ESR1ESR2CYP3A4 | |
| SCHEMBL368272 | 0.69 | ESR1 (1.00) | HSD17B1HSD17B2ESR1ESR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GILLESPIE PAUL | 2009-06-18 | — | — | US | disclosed |
| CN-101068803-A | Biaryloxymethylarene carboxylic acid compounds | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, GYS1, GSK3A | HSD17B1 19/4885HSD17B2 18/4885ESR1 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.