Pyrimidine — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	4/20	0.36

▸	TGM2	P21980	4/20	0.35

▸	PTPN1	P18031	1/20	0.33

▸	PTPN11	Q06124	1/20	0.33

▸	EGFR	P00533	7/20	0.33

▸	ITK	Q08881	4/20	0.33

▸	GSTO1	P78417	3/20	0.32

▸	JAK3	P52333	1/20	0.32

▸	F13A1	P00488	2/20	0.31

▸	TGM1	P22735	2/20	0.31

▸	TGM3	Q08188	1/20	0.31

▸	FYN	P06241	1/20	0.31

▸	SRC	P12931	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Sulfuric Acid SCHEMBL5242393	0.88	TGM2 (0.37)	BTKTGM2EGFRITKGSTO1
Sulfuric Acid SCHEMBL4458775	0.77	EGFR (0.41)	BTKTGM2EGFRJAK3FYN
Sulfuric Acid SCHEMBL5537630	0.74	MAPK3 (0.37)	TGM2EGFRITKF13A1TGM1
Sulfuric Acid SCHEMBL5243123	0.74	NPC1 (0.44)	TGM2PTPN1PTPN11EGFRITK
Sulfuric Acid SCHEMBL5244029	0.70	MAPK3 (0.41)	TGM2PTPN1PTPN11EGFRITK
SCHEMBL4452979	0.69	TGM2 (0.46)	TGM2PTPN1PTPN11EGFRGSTO1
SCHEMBL7641546	0.66	TGM2 (0.50)	TGM2PTPN1PTPN11EGFRITK
SCHEMBL22287107	0.65	TGM2 (0.39)	TGM2PTPN1PTPN11EGFRGSTO1
SCHEMBL5931306	0.65	TGM2 (0.44)	TGM2PTPN1PTPN11EGFRGSTO1
Pyrimidine SCHEMBL389598	0.65	NAPRT (0.42)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20070265365-A1	Water Soluble Polymers Containing Vinyl Unsaturation, Their Crosslinking and Process for Preparation Thereof	COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN)	2007-11-15	—	—	US	claimed
US-7560522-B2	Inclusion complexes of unsaturated monomers, their polymers and process for preparation thereof	COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN)	2009-07-14	—	—	US	disclosed
US-20070265365-A1	Water Soluble Polymers Containing Vinyl Unsaturation, Their Crosslinking and Process for Preparation Thereof	COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN)	2007-11-15	—	—	US	disclosed
US-20070213486-A1	Inclusion complexes of unsaturated monomers, their polymers and process for preparation thereof	PATIL PRERANA M	2007-09-13	—	—	US	disclosed
US-20070213489-A1	Inclusion complexes of unsaturated monomers, their polymers and process for preparation thereof	PATIL PRERANA M	2007-09-13	—	—	US	disclosed
US-20070213470-A1	Inclusion complexes of unsaturated monomers, their polymers and process for preparation thereof	PATIL PRERANA M	2007-09-13	—	—	US	disclosed
US-20060094844-A1	Inclusion complexes of unsaturated monomers, their polymers and process for preparation thereof	COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH	2006-05-04	—	—	US	disclosed