SCHEMBL4457465

SCHEMBL4457465

CC(C)C1=Cc2c(cccc2-c2ccccc2)[CH]1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 3/20 0.35
CDC25A P30304 2/20 0.35
PDCD1 Q15116 1/20 0.33
CD274 Q9NZQ7 1/20 0.33
METAP2 P50579 2/20 0.32
ALDH1A1 P00352 3/20 0.31
HSD17B10 Q99714 2/20 0.31
HPGD P15428 1/20 0.31
BCL2L1 Q07817 1/20 0.31
CYP2A6 P11509 1/20 0.31
MAPK1 P28482 1/20 0.31
PLK4 O00444 1/20 0.31
MAPK9 P45984 1/20 0.31
LIMK1 P53667 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
AKT3 Q9Y243 1/20 0.31
ADORA3 P0DMS8 1/20 0.30
ADORA2A P29274 1/20 0.30
ADORA1 P30542 1/20 0.30
PTPN1 P18031 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27757699 0.98 CDC25A (0.34) CDC25BCDC25APDCD1CD274METAP2
SCHEMBL28030823 0.94 CDC25A (0.32) CDC25BCDC25ACYP2A6
SCHEMBL27495777 0.94 CDC25A (0.32) CDC25BCDC25ACYP2A6
SCHEMBL15603402 0.93 CDC25A (0.33) CDC25BCDC25APDCD1CD274METAP2
SCHEMBL1241787 0.91 CDC25A (0.32) CDC25BCDC25A
SCHEMBL15163555 0.87 MEN1 (0.36) CDC25BCDC25A
SCHEMBL27706881 0.87 ADORA3 (0.34) CDC25BCDC25AADORA3
SCHEMBL27757770 0.85 MEN1 (0.35)
SCHEMBL4457396 0.84 PDCD1 (0.33) PDCD1CD274
SCHEMBL15163516 0.84 PTAFR (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105008408-B METHOD FOR PRODUCING ETHYLENE/[alpha]-OLEFIN COPOLYMER 日本聚乙烯株式会社 2017-05-10 CN disclosed
CN-105026408-A Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORP 2015-11-04 CN disclosed
CN-105008408-A METHOD FOR PRODUCING ETHYLENE/[alpha]-OLEFIN COPOLYMER JAPAN POLYETHYLENE CORP 2015-10-28 CN disclosed
CN-104136525-A Propylene-ethylene copolymer resin composition, and molded product, film and sheet thereof JAPAN POLYPROPYLENE CORP 2014-11-05 CN disclosed
EP-1548023-B1 Transition metal compound, catalyst system and the use of the latter for the polymerisation and copolymerisation of olefins BASELL POLYOLEFINE GMBH (DE) 2013-08-14 EP disclosed
CN-101061142-B Propylene-based terpolymers BASELL POLYOLEFINE GMBH 2012-04-18 CN disclosed
CN-101056901-B Process for the preparation of 1-butene/propylene copolymers BASELL POLYOLEFINE GMBH 2010-12-08 CN disclosed
US-7569651-B2 Transition metal compound, ligand system, catalyst system and its use for the polymerization and copolymerization of olefins BASELL POLYPROPYLEN GMBH (DE) 2009-08-04 US disclosed
CN-100494269-C Solvent dispersion of composite resin and uses thereof MITSUI CHEMICALS INC (JP) 2009-06-03 CN disclosed
CN-100473669-C Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and preparation of polyolefins BASELL POLYOLEFINE GMBH (DE) 2009-04-01 CN disclosed
CN-1138680-C Container for heating and sterilizing ������ѧ��ʽ���� 2004-02-18 CN disclosed
US-6677441-B2 CATIONIC GROUP 3 OR LANTHANIDE METAL COMPLEX STABILIZED BY A MONOANIONIC BIDENTATE ANCILLARY LIGAND AND TWO MONOANIONIC LIGANDS; COORDINATION POLYMERIZATION OF OLEFINS EXXONMOBIL CHEMICAL PATENTS INC. 2004-01-13 US disclosed
US-20030149199-A1 Transition metal compound, ligand system, catalyst system and the use of the latter for polymerisation and copolymerisation of olefins BASELL POLYPROPYLEN GMBH (DE) 2003-08-07 US disclosed
WO-2003057705-A1 PREPARATION OF SILICON-BRIDGED METALLOCENE COMPOUNDS BASELL POLYOLEFINE GMBH (DE) 2003-07-17 WO disclosed
US-6455458-B1 HIGH MOLECULAR WEIGHT POLYOLEFIN; GROUP 4 TRANSITION METAL COMPLEXES HAVING A BIDENTATE ANCILLARY LIGAND SYSTEM OF ONE CYCLOPENTADIENYL GROUP BOUND TO THE TRANSITION METAL AND A GROUP 15 OR GROUP 16 ATOM COVALENTLY BOUND THROUGH A BRIDGING EXXONMOBIL CHEMICAL PATENTS INC. 2002-09-24 US disclosed
US-6403773-B1 GROUP 3 OR LANTHANIDE METAL COMPLEX WHICH FORMS ACTIVE CATIONIC CATALYST SPECIES FOR PRODUCTION OF POLYOLEFINS HAVING HIGH MOLECULAR WEIGHT EXXON MOBIL CHEMICAL PATENTS INC. 2002-06-11 US disclosed
CN-1310730-A Ethylene-alpha-olefin-nonconjugated polyene copolymer rubber, rubber composition for sealing, molded rubber article for sealing, and process for producing molded article MITSUI CHEMICALS INC (JP) 2001-08-29 CN disclosed
CN-1065866-C Process for converting achiral meso form of ansa-metallocene complex into chiral racemic form BASF AG (DE) 2001-05-16 CN disclosed
CN-1259467-A Container for heating and sterilizing MITRUI CHEMICAL CO LTD (JP) 2000-07-12 CN disclosed
CN-1190398-A Process for converting achiral meso form of ansa-metallocene complex into chiral racemic form BASF AG (DE) 1998-08-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030149199-A1 Transition metal compound, ligand system, catalyst system and the use of the latter for polymerisation and copolymerisation of olefins PORCN, PGR, PPOX CDC25B 2555/4885CDC25A 2764/4885PDCD1 178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.