SCHEMBL4458549

SCHEMBL4458549

CCS(=O)(=O)c1cccc(O)c1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 1/20 0.44
COMT P21964 1/20 0.42
G6PD P11413 1/20 0.41
CASP7 P55210 1/20 0.41
CASP6 P55212 1/20 0.41
STAT3 P40763 1/20 0.40
GAA P10253 1/20 0.38
PSIP1 O75475 2/20 0.38
AURKA O14965 1/20 0.38
AURKB Q96GD4 1/20 0.38
APEX1 P27695 1/20 0.37
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA7 P43166 2/20 0.36
CA9 Q16790 2/20 0.36
CA14 Q9ULX7 2/20 0.36
CYP2C9 P11712 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2925051 0.83 EPHX2 (0.49) CDK2CA2
SCHEMBL10708504 0.81 CA2 (0.49) CDK2G6PDCASP7CASP6STAT3
SCHEMBL9359459 0.80 CDK2 (0.47) CDK2G6PDCASP7CASP6STAT3
SCHEMBL635927 0.79 CDK2 (0.61) CDK2G6PDCASP7CASP6STAT3
SCHEMBL29545862 0.79 CDK2 (0.50) CDK2G6PDCASP7CASP6STAT3
SCHEMBL565103 0.79 CDK2 (0.50) CDK2G6PDCASP7CASP6STAT3
SCHEMBL672426 0.79 PSIP1 (0.48) CDK2COMTGAAPSIP1APEX1
SCHEMBL11785533 0.79 KDM4E (0.48) CDK2G6PDCASP7CASP6STAT3
SCHEMBL29101963 0.78 COMT (0.44) CDK2COMTCASP7STAT3GAA
SCHEMBL3030721 0.78 AURKA (0.53) CDK2COMTG6PDCASP7CASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106083667-B A kind of synthetic method of 2 amino (4 ethylsulfonyl) phenol 杭州福斯特药业有限公司 2018-01-05 CN claimed
CN-106083667-A A kind of synthetic method of 2 amino (4 ethylsulfonyl) phenol 杭州福斯特药业有限公司 2016-11-09 CN claimed
CN-106083667-B A kind of synthetic method of 2 amino (4 ethylsulfonyl) phenol 杭州福斯特药业有限公司 2018-01-05 CN disclosed
CN-106083667-A A kind of synthetic method of 2 amino (4 ethylsulfonyl) phenol 杭州福斯特药业有限公司 2016-11-09 CN disclosed
WO-2014066237-A1 PROCESSES FOR THE SEPARATION OF ORES GEORGIA-PACIFIC CHEMICALS LLC (US) 2014-05-01 WO disclosed
US-20130217791-A1 MATERIALS AND PROCESS FOR ENHANCING SELECTIVE SEPARATIONS GEORGIA-PACIFIC CHEMICALS LLC (US) 2013-08-22 US disclosed
US-8425781-B2 Materials and process for enhancing selective separations GEORGIA-PACIFIC CHEMICALS LLC (US) 2013-04-23 US disclosed
US-20090301972-A1 MATERIALS AND PROCESS FOR ENHANCING SELECTIVE SEPARATIONS GEORGIA-PACIFIC CHEMICALS LLC (US) 2009-12-10 US disclosed
EP-0092909-B1 PROCESS FOR PRODUCING AMINOPHENYL-BETA-HYDROXYETHYLSULFONE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-08-19 EP disclosed
EP-0146007-A1 Process for the preparation of 5-hydroxyethylsulphonyl-2-aminophenol (or ethers) HOECHST AKTIENGESELLSCHAFT (DE) 1985-06-26 EP disclosed