Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clotiazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.55 |
| ▸ | GABRA5 known ✓ | P31644 | 4/20 | 0.55 |
| ▸ | GABRA2 known ✓ | P47869 | 4/20 | 0.55 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.55 |
| ▸ | GABRG2 known ✓ | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 known ✓ | P28472 | 3/20 | 0.45 |
| ▸ | GABRA3 known ✓ | P34903 | 3/20 | 0.45 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.45 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.45 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.45 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.45 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.45 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.45 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.45 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.45 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clotiazepam SCHEMBL29368955 | 1.00 | OPRK1 (0.63) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Clotiazepam SCHEMBL28086544 | 0.91 | OPRK1 (0.54) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Etizolam SCHEMBL28086661 | 0.88 | OPRK1 (0.85) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Clonazepam SCHEMBL14783900 | 0.82 | GABRA1 (0.69) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL15652960 | 0.81 | OPRK1 (0.59) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL8668108 | 0.81 | OPRK1 (0.59) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Clotiazepam SCHEMBL6130078 | 0.79 | GABRA1 (0.64) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL8928481 | 0.79 | OPRK1 (0.84) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL10825033 | 0.78 | OPRK1 (0.42) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL8668139 | 0.78 | GAA (0.65) | OPRK1PDE4DGABRA1GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4694 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611968-A1 | METHOD AND CALIBRATION SYSTEM FOR CALIBRATING AUTONOMOUS MOBILE MACHINES | Siemens Aktiengesellschaft (DE) | 2025-09-10 | — | — | EP | claimed |
| EP-4570250-A2 | COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER | Otsuka Pharmaceutical Co., Ltd. (JP) | 2025-06-18 | — | — | EP | claimed |
| US-20250179064-A1 | BENZOQUINOLONE INHIBITORS OF VMAT2 | AUSPEX PHARMACEUTICALS LLC | 2025-06-05 | — | — | US | claimed |
| US-20250177385-A1 | COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2025-06-05 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119648764-A | Optical and SAR image registration method and system based on multi-scale phase antisymmetry | 西安交通大学 | 2025-03-18 | — | — | CN | claimed |
| US-12133922-B2 | Abuse resistant capsule | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2024-11-05 | — | — | US | claimed |
| EP-3706762-B1 | N4-HYDROXYCYTIDINE DERIVATIVE AND ANTI-VIRAL USES RELATED THERETO | UNIV EMORY (US) | 2024-10-16 | — | — | EP | claimed |
| WO-2024126774-A1 | METHOD AND CALIBRATION SYSTEM FOR CALIBRATING AUTONOMOUS MOBILE MACHINES | SIEMENS AKTIENGESELLSCHAFT (DE) | 2024-06-20 | — | — | WO | claimed |
| US-20240156811-A1 | COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-05-16 | — | — | US | claimed |
| US-4721709-A | Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions | PYARE SETH (CH) | 1988-01-26 | — | — | US | claimed |
| EP-0247131-A1 | PROCEDURE AND DEVICE FOR CROSSPOINT-SWITCHING OF SYNCHRONOUS OR ASYNCHRONOUS DATA TRANSMISSION LINES, PARTICULARLY FOR SERIAL DATA TRANSMISSION | MTA KÖZPONTI FIZIKAI KUTATO INTEZETE (HU) | 1987-12-02 | — | — | EP | claimed |
| WO-1987003447-A1 | PROCEDURE AND DEVICE FOR CROSSPOINT-SWITCHING OF SYNCHRONOUS OR ASYNCHRONOUS DATA TRANSMISSION LINES, PARTICULARLY FOR SERIAL DATA TRANSMISSION | MTA KÖZPONTI FIZIKAI KUTATÓ INTÉZETE (HU) | 1987-06-04 | — | — | WO | claimed |
| EP-0216765-A1 | OPTICAL RECEIVER. | BELL TELEPHONE MFG (BE) | 1987-04-08 | — | — | EP | claimed |
| WO-1985004997-A1 | OPTICAL RECEIVER | BELL TELEPHONE MANUFACTURING COMPANY, N.V. (BE) | 1985-11-07 | — | — | WO | claimed |
| WO-1984001739-A1 | ORGANIZATION APPARATUS FOR TRAVELLING, FOR THE OFFICE, THE SCHOOL AND AT HOME | KOLLEKTIVGESELLSCHAFT EBERHARD (CH) | 1984-05-10 | — | — | WO | claimed |
| EP-0025043-A1 | LOCKING MEANS FOR SAFETY BELTS | LINDBLAD, Stig Martin (US) | 1981-03-18 | — | — | EP | claimed |
| EP-0020749-A1 | EXCISING PATHOLOGICAL TISSUE USING A BEAM OF RADIATION | DAVI, Samantha K. (US) | 1981-01-07 | — | — | EP | claimed |
| WO-1980001877-A1 | LOCKING MEANS FOR SAFETY BELTS | LINDBLAD S M | 1980-09-18 | — | — | WO | claimed |
| WO-1980001238-A1 | EXCISING PATHOLOGICAL TISSUE USING A BEAM OF RADIATION | DAVI S | 1980-06-26 | — | — | WO | claimed |