Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Etizolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.85 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.85 |
| ▸ | PTAFR | P25105 | 19/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etizolam SCHEMBL42920 | 0.92 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL30665015 | 0.92 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL10869413 | 0.90 | OPRK1 (0.90) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Clotiazepam SCHEMBL44592 | 0.88 | OPRK1 (0.63) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Clotiazepam SCHEMBL29368955 | 0.88 | OPRK1 (0.63) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL28142121 | 0.86 | OPRK1 (0.69) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL8928483 | 0.84 | OPRK1 (0.84) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL8928481 | 0.84 | OPRK1 (0.84) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL10469718 | 0.83 | PTAFR (0.88) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9667837 | 0.82 | OPRK1 (0.81) | OPRK1PDE4DPTAFRCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |