Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 6/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451826 | 0.87 | KMO (0.39) | SYKEGFR | |
| Trifluoroacetic Acid SCHEMBL4467339 | 0.83 | MAPK13 (0.47) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL13959343 | 0.76 | MAPK13 (0.50) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL4466566 | 0.75 | KMO (0.38) | SYK | |
| SCHEMBL4152433 | 0.70 | ABL1 (0.37) | SYK | |
| SCHEMBL4458385 | 0.68 | RXRB (0.37) | HTR1A | |
| SCHEMBL4466569 | 0.68 | GPR119 (0.50) | P2RY14SYK | |
| Trifluoroacetic Acid SCHEMBL4451796 | 0.68 | MEN1 (0.46) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL4153075 | 0.66 | CHRNB2 (0.39) | — | |
| SCHEMBL4451823 | 0.65 | GRM1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030012-A1 | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030012-A1 | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators | CXCR3, CXCR1, CXCR5 | CSNK1A1 2819/4885CSNK1D 3081/4885RPS6KA3 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.