SCHEMBL446052

SCHEMBL446052

Cc1ccc(-c2cc[c]c(C)c2C)c(C)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.37
GAA P10253 1/20 0.37
TDP1 Q9NUW8 2/20 0.34
TP53 P04637 1/20 0.34
RAPGEF4 Q8WZA2 3/20 0.33
LMNA P02545 1/20 0.32
ALPL P05186 1/20 0.32
CA9 Q16790 1/20 0.32
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31
NPC1 O15118 2/20 0.31
RAB9A P51151 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ELANE P08246 1/20 0.31
ALDH1A1 P00352 2/20 0.30
KDM4E B2RXH2 1/20 0.30
HPGD P15428 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15453986 0.85 ALDH1A1 (0.34) MAPTGAATDP1TP53RAPGEF4
SCHEMBL8064215 0.77 MAPT (0.37) MAPTGAATDP1TP53LMNA
SCHEMBL3043421 0.76 TDP1 (0.52) MAPTGAATDP1TP53RAPGEF4
SCHEMBL31547677 0.76 TDP1 (0.52) MAPTGAATDP1TP53RAPGEF4
SCHEMBL6425763 0.74 GAA (0.35) MAPTGAATDP1TP53RAPGEF4
SCHEMBL8465845 0.74 ACHE (0.35) TDP1MAOBNPC1RAB9AMEN1
SCHEMBL23967969 0.73 MAPT (0.42) MAPTGAATDP1TP53RAPGEF4
SCHEMBL20554010 0.72 MAPT (0.39) MAPTGAATDP1TP53RAPGEF4
SCHEMBL10939076 0.72 MAPT (0.39) MAPTGAATDP1TP53RAPGEF4
SCHEMBL5147351 0.72 TRPA1 (0.37) RAPGEF4CA9ALDH1A1SMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10376869-B2 Process for oligomerization DOW GLOBAL TECHNOLOGIES LLC (US) 2019-08-13 US disclosed
US-20180154344-A1 PROCESS FOR OLIGOMERIZATION DOW GLOBAL TECHNOLOGIES LLC (US) 2018-06-07 US disclosed
US-9133370-B2 Methods of mercaptanizing olefinic hydrocarbons and compositions produced therefrom CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2015-09-15 US disclosed
US-20130240780-A1 Methods of Mercaptanizing Olefinic Hydrocarbons and Compositions Produced Therefrom CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2013-09-19 US disclosed
US-8148545-B2 Processes for the synthesis of γ nitrocarbonyl and γ dicarbonyl compounds and their pyrrole derivatives CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-04-03 US disclosed
US-20120064322-A1 AMINOPLAST-POLYTHIOL COMPOSITIONS AND ARTICLES PRODUCED THEREFROM CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-03-15 US disclosed
US-20120035291-A1 METHODS OF MERCAPTANIZING OLEFINIC HYDROCARBONS AND COMPOSITIONS PRODUCED THEREFROM CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-02-09 US disclosed
EP-0212907-B1 PROCESS FOR FABRICATING OPTICAL RECORDING MEDIA MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-03-13 EP disclosed
EP-0203826-B1 OPTICAL RECORDING MEDIUM AND METHOD OF RECORDING THEREON MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-03-06 EP disclosed
US-4798781-A PHTHALO/NAPHTHALOCYANINE DYE/ MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1989-01-17 US disclosed
US-4766054-A CONTAINING PHTHALO(NAPHTHALO)CYANINE DYE MITSUI TOATSU CHEMICAL, INC. (JP) 1988-08-23 US disclosed
EP-0212907-A2 Process for fabricating optical recording media MITSUI TOATSU CHEMICALS, Inc. (JP) 1987-03-04 EP disclosed
EP-0203826-A2 Optical recording medium and method of recording thereon MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-12-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10376869-B2 Process for oligomerization OXER1, NOD1, LIG1 MAPT 2631/4885GAA 3107/4885TDP1 273/4885
US-20180154344-A1 PROCESS FOR OLIGOMERIZATION OXER1, NOD1, LIG1 MAPT 2631/4885GAA 3107/4885TDP1 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.