Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16478541 | 0.81 | ALDH1A1 (0.40) | ALDH1A1CYP1A1CYP1B1PKMFLT1 | |
| SCHEMBL152815 | 0.78 | RAPGEF4 (0.46) | ALDH1A1TRPV4CYP1A1CYP1B1PKM | |
| SCHEMBL2496728 | 0.78 | CYP1A2 (0.47) | ALDH1A1TRPV4CYP1A1CYP1B1KDM4E | |
| SCHEMBL2205517 | 0.77 | RAPGEF4 (0.44) | ALDH1A1TRPV4CYP1A1CYP1B1PKM | |
| SCHEMBL22146099 | 0.77 | PKM (0.48) | ALDH1A1TRPV4CYP1A1CYP1B1PKM | |
| 1,3,5-Trimethoxybenzene SCHEMBL2496933 | 0.76 | ALDH1A1 (0.65) | ALDH1A1CYP1A1CYP1B1PKMCYP1A2 | |
| SCHEMBL4512524 | 0.75 | CA1 (0.35) | ALDH1A1TRPV4KDM4EGAAMAPT | |
| SCHEMBL181647 | 0.74 | ALDH1A1 (0.43) | ALDH1A1TRPV4CNR1CYP3A4AHR | |
| SCHEMBL2833625 | 0.74 | RAPGEF4 (0.42) | ALDH1A1CYP1A1CYP1B1LMNACYP1A2 | |
| SCHEMBL4065639 | 0.74 | TRPV4 (0.53) | ALDH1A1TRPV4FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538111-B2 | Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | LABORATOIRES FOURNIER S.A. (FR) | 2009-05-26 | — | — | US | disclosed |
| US-20060178360-A1 | Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | LABORATOIRES FOURNIER S.A. (FR) | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178360-A1 | Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | LTB4R2, BDKRB2, TBXA2R | ALDH1A1 283/4885TRPV4 113/4885CYP1A1 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.