Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481998 | 0.89 | PTGS2 (0.43) | PTGS2PTGES | |
| SCHEMBL4471452 | 0.80 | KDM1A (0.44) | PTGS2GRIN1GRIN2B | |
| SCHEMBL4479235 | 0.76 | SLC2A1 (0.42) | PTGS2GRIN1GRIN2BSLC2A1 | |
| SCHEMBL13761581 | 0.74 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL4483764 | 0.74 | PTGS2 (0.40) | GRM5PTGS2 | |
| SCHEMBL9259828 | 0.72 | PTGS2 (0.61) | PTGS2 | |
| SCHEMBL9271388 | 0.70 | PTGS2 (0.45) | PTGS2 | |
| SCHEMBL4470825 | 0.69 | PTGES (0.44) | PTGS2PTGESSLC2A1 | |
| SCHEMBL4468876 | 0.69 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL4477921 | 0.68 | DGAT1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579353-B2 | Pyridinone derivatives against malaria | GLAXO GROUP LIMITED (GB) | 2009-08-25 | — | — | US | disclosed |
| US-20080287461-A1 | Pyridinone Derivatives Against Malaria | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287461-A1 | Pyridinone Derivatives Against Malaria | G6PD, PNPO, PLPBP | GRM5 1948/4885PTGS2 1111/4885GRIN1 2803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.