Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471204 | 0.84 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL4475059 | 0.82 | ALDH1A1 (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL6770900 | 0.80 | SLC6A4 (0.44) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL6770174 | 0.79 | SLC6A4 (0.47) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL4468911 | 0.77 | SLC6A2 (0.38) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL8911597 | 0.75 | PRKCZ (0.48) | ALDH1A1LMNAHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL14191121 | 0.75 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL31378993 | 0.75 | HTR1A (0.42) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL6702600 | 0.75 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A2 | |
| SCHEMBL8069514 | 0.74 | P2RY1 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592344-B2 | NK1 and NK2-antagonists and compositions and methods of using the same | SOLVAY PHARMACEUTICALS GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| EP-1979319-A1 | NOVEL DUAL NK2/NK3-ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THEIR PREPARATIONS | Solvay Pharmaceuticals GmbH (DE) | 2008-10-15 | — | — | EP | disclosed |
| EP-1954678-A1 | NOVEL NK1 AND NK2 ANTAGONISTS | Solvay Pharmaceuticals GmbH (DE) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007088181-A1 | NOVEL DUAL NK2/NK3-ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THEIR PREPARATIONS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-08-09 | — | — | WO | disclosed |
| US-20070149537-A1 | NK1 and NK2-antagonists and compositions and methods of using the same | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-06-28 | — | — | US | disclosed |
| WO-2007063086-A1 | NOVEL NK1 AND NK2 ANTAGONISTS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149537-A1 | NK1 and NK2-antagonists and compositions and methods of using the same | HRH2, PROKR2, BDKRB2 | ALDH1A1 1818/4885LMNA 2555/4885HTT 1686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.