SCHEMBL4477762

SCHEMBL4477762

COC(=O)c1ccccc1-n1nc(C(F)(F)F)cc1C(=O)Nc1c(C)cccc1C(=O)NC(C)C

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 4/20 0.42
F10 P00742 2/20 0.41
TP53 P04637 1/20 0.41
CRACR2A Q9BSW2 2/20 0.40
KLKB1 P03952 4/20 0.39
DHODH Q02127 1/20 0.39
F2 P00734 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1383820 0.90 CRACR2A (0.45) CARM1F10TP53CRACR2AKLKB1
SCHEMBL4769625 0.89 CARM1 (0.42) CARM1F10TP53CRACR2AKLKB1
SCHEMBL4481841 0.88 F10 (0.46) CARM1F10KLKB1F2
SCHEMBL3278308 0.87 KLKB1 (0.50) CARM1TP53CRACR2AKLKB1
SCHEMBL4484650 0.87 F10 (0.53) CARM1F10KLKB1F2
SCHEMBL4480973 0.86 F10 (0.46) CARM1F10F2
SCHEMBL5653070 0.83 F10 (0.48) CARM1F10KLKB1F2
SCHEMBL3276731 0.82 RIPK1 (0.40) CARM1TP53CRACR2AKLKB1DHODH
SCHEMBL4666449 0.81 AURKA (0.48) CARM1TP53CRACR2AKLKB1DHODH
SCHEMBL29393434 0.80 DHODH (0.39) CARM1TP53CRACR2AKLKB1DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7541377-B2 Substituted anthranilamides for controlling invertebrate pests E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-06-02 US disclosed
EP-1417176-B1 SUBSTITUTED ANTHRANILAMIDES FOR CONTROLLING INVERTEBRATE PESTS DU PONT (US) 2008-12-17 EP disclosed
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests FINKELSTEIN BRUCE L 2007-08-30 US disclosed
US-7199138-B2 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-04-03 US disclosed
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 CARM1 1314/4885F10 393/4885TP53 4597/4885
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 CARM1 1357/4885F10 415/4885TP53 4606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.