SCHEMBL4481841

SCHEMBL4481841

Cc1cccc(C(=O)NC(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ccccc1CO

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
F10 P00742 13/20 0.46
F2 P00734 6/20 0.46
CARM1 Q86X55 2/20 0.42
KLKB1 P03952 2/20 0.41
PROC P04070 1/20 0.41
PRSS1 P07477 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4484650 0.92 F10 (0.53) F10F2CARM1KLKB1PROC
SCHEMBL4769625 0.90 CARM1 (0.42) F10F2CARM1KLKB1
SCHEMBL4480973 0.89 F10 (0.46) F10F2CARM1
SCHEMBL1383820 0.89 CRACR2A (0.45) F10F2CARM1KLKB1
SCHEMBL4477762 0.88 CARM1 (0.42) F10F2CARM1KLKB1
SCHEMBL5653070 0.86 F10 (0.48) F10F2CARM1KLKB1PROC
SCHEMBL3278308 0.86 KLKB1 (0.50) CARM1KLKB1
SCHEMBL4666449 0.82 AURKA (0.48) CARM1KLKB1
SCHEMBL3276731 0.81 RIPK1 (0.40) CARM1KLKB1
SCHEMBL29393434 0.80 DHODH (0.39) CARM1KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7541377-B2 Substituted anthranilamides for controlling invertebrate pests E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-06-02 US claimed
EP-1417176-B1 SUBSTITUTED ANTHRANILAMIDES FOR CONTROLLING INVERTEBRATE PESTS DU PONT (US) 2008-12-17 EP claimed
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests FINKELSTEIN BRUCE L 2007-08-30 US claimed
CN-1653051-A Substituted anthranilamides for controlling invertebrate pests DU PONT (US) 2005-08-10 CN claimed
US-7541377-B2 Substituted anthranilamides for controlling invertebrate pests E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-06-02 US disclosed
CN-100453532-C Substituted anthranilamides for controlling invertebrate pests DU PONT (US) 2009-01-21 CN disclosed
EP-1417176-B1 SUBSTITUTED ANTHRANILAMIDES FOR CONTROLLING INVERTEBRATE PESTS DU PONT (US) 2008-12-17 EP disclosed
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests FINKELSTEIN BRUCE L 2007-08-30 US disclosed
US-7199138-B2 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-04-03 US disclosed
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-22 US disclosed
CN-1653051-A Substituted anthranilamides for controlling invertebrate pests DU PONT (US) 2005-08-10 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 F10 393/4885F2 383/4885CARM1 1314/4885
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 F10 415/4885F2 324/4885CARM1 1357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.