Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.56 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.56 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | FDPS | P14324 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21991112 | 0.88 | SIGMAR1 (0.60) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL9261309 | 0.87 | SIGMAR1 (0.47) | CARM1PRMT6PRMT8SIGMAR1ALDH1A1 | |
| SCHEMBL16247246 | 0.85 | CARM1 (0.60) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL27376506 | 0.85 | CARM1 (0.45) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL15269721 | 0.83 | MEN1 (0.44) | SIGMAR1TSHRALDH1A1AOC3RIPK1 | |
| SCHEMBL7057713 | 0.82 | CARM1 (0.53) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL16039984 | 0.81 | CARM1 (0.51) | CARM1PRMT6PRMT8SIGMAR1ALDH1A1 | |
| SCHEMBL11112967 | 0.80 | SMN1; SMN2 (0.60) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL7055109 | 0.80 | CARM1 (0.75) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL10287670 | 0.79 | BCHE (0.48) | SIGMAR1TSHRFDPSMAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090182010-A1 | COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-07-16 | — | — | US | disclosed |
| US-7528253-B2 | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity | THERAVANCE, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| EP-1778626-A1 | COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | Theravance, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20060116398-A1 | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity | THERAVANCE BIOPHARMA R&D IP, LLC | 2006-06-01 | — | — | US | disclosed |
| WO-2006023457-A1 | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | THERAVANCE, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182010-A1 | COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ADRB2, ADRA2B, ADRA2A | CARM1 1194/4885PRMT6 1196/4885PRMT8 952/4885 |
| US-20060116398-A1 | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity | ADRB2, ADRA2B, ADRB1 | CARM1 1283/4885PRMT6 1374/4885PRMT8 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.