Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PPID | Q08752 | 3/20 | 0.34 |
| ▸ | PPIG | Q13427 | 2/20 | 0.34 |
| ▸ | PPIB | P23284 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776278 | 0.70 | RIPK1 (0.65) | HSD11B1HSP90AA1HSP90AB1RIPK1PPID | |
| SCHEMBL5822054 | 0.68 | GAA (0.49) | HSD11B1 | |
| SCHEMBL5194432 | 0.68 | HSP90AA1 (0.58) | HSD11B1HSP90AA1HSP90AB1PPIDPPIG | |
| SCHEMBL17093004 | 0.67 | RIPK1 (0.51) | HSP90AA1HSP90AB1RIPK1ALDH1A1 | |
| SCHEMBL938757 | 0.66 | RIPK1 (0.59) | HSD11B1HSP90AA1HSP90AB1RIPK1 | |
| SCHEMBL31648898 | 0.66 | HSP90AA1 (0.50) | HSD11B1HSP90AA1HSP90AB1PPIDPPIG | |
| SCHEMBL38659451 | 0.65 | HSD11B1 (0.51) | HSD11B1MAPK1RIPK1NPC1ALDH1A1 | |
| SCHEMBL4971105 | 0.65 | AR (0.54) | MAPK1NPC1ALDH1A1 | |
| SCHEMBL8296762 | 0.65 | HSD11B1 (0.51) | HSD11B1MAPK1RIPK1NPC1ALDH1A1 | |
| SCHEMBL28511386 | 0.65 | MEN1 (0.55) | HSP90AA1HSP90AB1PPIDPPIGPPIB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | HCRTR1, HCRTR2, NPSR1 | HSD11B1 2826/4885MAPK1 3740/4885HSP90AA1 2356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.