Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 6/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187011 | 0.81 | L3MBTL1 (0.42) | MAPTMEN1ALDH1A1CYP1A2TSHR | |
| SCHEMBL12810668 | 0.76 | CRHR1 (0.40) | CMA1CYP17A1MAPTTBXAS1CRHR1 | |
| SCHEMBL1251629 | 0.72 | MPO (0.40) | CMA1CYP17A1MAPTCRHR1KMT2A | |
| SCHEMBL1251627 | 0.72 | CMA1 (0.38) | CMA1CYP17A1MAPTCRHR1PFKFB4 | |
| SCHEMBL1251780 | 0.71 | CYP17A1 (0.49) | CMA1CYP17A1CRHR1PFKFB4ALDH1A1 | |
| SCHEMBL5331340 | 0.70 | MTNR1A (0.38) | CMA1CYP17A1MAPTTBXAS1CRHR1 | |
| SCHEMBL10033650 | 0.69 | CYP17A1 (0.39) | CMA1CYP17A1CRHR1DHODHPFKFB4 | |
| SCHEMBL2614663 | 0.68 | CYP17A1 (0.42) | CMA1CYP17A1CRHR1PFKFB4 | |
| SCHEMBL4774640 | 0.68 | MTNR1A (0.38) | CMA1CYP17A1MAPTTBXAS1MTNR1A | |
| SCHEMBL4342850 | 0.67 | CMA1 (0.41) | CMA1CYP17A1TBXAS1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664011-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1664011-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020917-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |