Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.70 |
| ▸ | CTSG | P08311 | 1/20 | 0.70 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.70 |
| ▸ | CMA1 | P23946 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamipron SCHEMBL605899 | 1.00 | PRSS1 (0.70) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL9717434 | 0.91 | MAPK1 (0.71) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL2033165 | 0.88 | MAPK1 (0.73) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL9717417 | 0.88 | ITGB3 (0.65) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL9829615 | 0.87 | GAA (0.57) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL3192014 | 0.87 | LMNA (0.77) | PRSS1CTSGCTRB1CMA1GAA | |
| Betamipron SCHEMBL28084518 | 0.87 | NPC1 (0.73) | PRSS1CTSGCTRB1CMA1SMN1; SMN2 | |
| SCHEMBL950223 | 0.86 | MAPK1 (0.83) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL2324530 | 0.86 | PRSS1 (0.64) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL5592824 | 0.86 | PRSS1 (0.68) | PRSS1CTSGCTRB1CMA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517858-B1 | Prodrugs of pharmaceuticals with improved bioavailability | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-14 | — | — | US | disclosed |
| EP-0837630-A4 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | UNIV CALIFORNIA (US) | 1998-11-25 | — | — | EP | disclosed |
| EP-0837630-A1 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996039831-A1 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |