Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216179 | 0.89 | ATM (0.54) | STING1KDM4ENR4A2CREBBPPBRM1 | |
| SCHEMBL5894412 | 0.79 | STING1 (0.56) | STING1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL384965 | 0.79 | STING1 (0.63) | STING1MEN1KMT2AGPR84 | |
| Hydrochloric Acid SCHEMBL9574627 | 0.78 | STING1 (0.55) | STING1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL1596152 | 0.77 | STING1 (0.61) | STING1NR4A2CREBBPPBRM1MEN1 | |
| SCHEMBL28736881 | 0.77 | STING1 (0.74) | STING1NR4A2CREBBPPBRM1ALDH1A1 | |
| Oxalic Acid SCHEMBL27559452 | 0.77 | ATM (0.77) | KDM4ENR4A2CREBBPPBRM1ALDH1A1 | |
| SCHEMBL1716641 | 0.76 | MAPT (0.52) | STING1KDM4ENR4A2CREBBPPBRM1 | |
| SCHEMBL4285209 | 0.76 | MAPT (0.52) | STING1KDM4ENR4A2CREBBPPBRM1 | |
| SCHEMBL4490274 | 0.75 | STING1 (0.59) | STING1KDM4ENR4A2CREBBPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-03 | — | — | US | disclosed |
| US-7579350-B2 | 5-Isobutyl-6-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridazin-3-yl]-piperidin-1-yl-methanone; mimetics of functionalized pyridazine derivatives having low molecular weight; alpha-helical binding ligands of natural receptors such as those of the peptide galanin or the protein Bcl | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-08-25 | — | — | US | disclosed |
| US-20060205728-A1 | Novel scaffolds for beta-helix mimicry | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205728-A1 | Novel scaffolds for beta-helix mimicry | HRH1, HEATR1, HSPH1 | STING1 1085/4885KDM4E 4668/4885NR4A2 83/4885 |
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | HRH1, HEATR1, PLEKHA1 | STING1 831/4885KDM4E 4601/4885NR4A2 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.