Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490745 | 0.82 | GRIA2 (0.40) | DHODHKDM4EALDH1A1HSD17B10USP2 | |
| SCHEMBL4492957 | 0.76 | GRIA2 (0.42) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL4491009 | 0.75 | ALDH1A1 (0.43) | DHODHKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4498679 | 0.72 | CCNC (0.36) | KDM4EALDH1A1HPGDLMNAHTT | |
| SCHEMBL4504195 | 0.71 | CCR1 (0.38) | KDM4EALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL4488870 | 0.70 | MEN1 (0.43) | DHODHKDM4EALDH1A1MEN1LMNA | |
| SCHEMBL4488653 | 0.70 | ERCC1 (0.38) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL4492339 | 0.69 | MAPT (0.34) | KDM4EALDH1A1HPGDMEN1LMNA | |
| SCHEMBL4480912 | 0.68 | — | — | |
| SCHEMBL4495477 | 0.68 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |