Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488653 | 0.79 | ERCC1 (0.38) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL4487479 | 0.78 | ECE1 (0.33) | SMN1; SMN2 | |
| SCHEMBL4491009 | 0.76 | ALDH1A1 (0.43) | MAPTATMKDM4EALDH1A1LMNA | |
| SCHEMBL4491753 | 0.73 | POLB (0.35) | MAPTATMKDM4ELMNAKMT2A | |
| SCHEMBL4498679 | 0.73 | CCNC (0.36) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL4490745 | 0.73 | GRIA2 (0.40) | KDM4EALDH1A1KMT2AALOX15MAPK1 | |
| SCHEMBL4504195 | 0.72 | CCR1 (0.38) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL4496740 | 0.72 | GRM5 (0.39) | MAPTKDM4EKMT2ATP53NPC1 | |
| SCHEMBL4488870 | 0.71 | MEN1 (0.43) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL4480912 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |