Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491009 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KDM4EPOLBHSD17B10HPGD | |
| SCHEMBL4492339 | 0.79 | MAPT (0.34) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL4498679 | 0.76 | CCNC (0.36) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL4487479 | 0.76 | ECE1 (0.33) | — | |
| SCHEMBL4490745 | 0.74 | GRIA2 (0.40) | ALDH1A1KDM4EKMT2AHSD17B10ALOX15 | |
| SCHEMBL4492957 | 0.72 | GRIA2 (0.42) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL4496740 | 0.72 | GRM5 (0.39) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL4488870 | 0.72 | MEN1 (0.43) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4489152 | 0.72 | TDP1 (0.44) | NPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL4491753 | 0.72 | POLB (0.35) | KDM4EMEN1KMT2APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |