Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491009 | 0.87 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL4490745 | 0.84 | GRIA2 (0.40) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4488870 | 0.82 | MEN1 (0.43) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4485664 | 0.80 | KDM4E (0.40) | CCNCCDK8KDM4EFNTAFNTB | |
| SCHEMBL4495477 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL4491745 | 0.80 | AR (0.43) | KDM4EALDH1A1MAPTPOLBRAB9A | |
| SCHEMBL4504195 | 0.77 | CCR1 (0.38) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4488653 | 0.76 | ERCC1 (0.38) | KDM4EALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL4491753 | 0.76 | POLB (0.35) | KDM4EMAPTLMNASMN1; SMN2POLB | |
| SCHEMBL4487479 | 0.75 | ECE1 (0.33) | SMN1; SMN2HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |