Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493393 | 0.88 | MAPK8 (0.68) | CASP3NPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL4509748 | 0.81 | ABCC1 (0.61) | NPC1RAB9AMAPK8MAPK10PTPN1 | |
| SCHEMBL2233522 | 0.77 | NPC1 (0.69) | CASP3NPC1RAB9APTPN1ABCC1 | |
| SCHEMBL20303095 | 0.77 | ABCC1 (0.54) | NPC1RAB9AMAPK8MAPK10PTPN1 | |
| SCHEMBL288676 | 0.75 | CFD (0.60) | NPC1RAB9AMAPK8MAPK10PTPN1 | |
| SCHEMBL11564307 | 0.75 | NPC1 (0.51) | CASP3NPC1RAB9AMAPK8HDAC3 | |
| SCHEMBL11564309 | 0.75 | NPC1 (0.62) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL7351218 | 0.75 | POLB (0.57) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL747058 | 0.74 | KDM4E (0.60) | NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL7268166 | 0.74 | MAOB (0.61) | CASP3NPC1RAB9APTPN1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | CASP3 389/4885NPC1 57/4885RAB9A 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.