Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507572 | 0.88 | CASP3 (0.60) | MAPK8MAPK10MAPK9CASP3NPC1 | |
| SCHEMBL2802258 | 0.82 | HPGD (0.62) | MAPK8MAPK10MAPK9L3MBTL1LMNA | |
| SCHEMBL1039299 | 0.81 | MAPK8 (1.00) | MAPK8MAPK10MAPK9L3MBTL1LMNA | |
| SCHEMBL15880510 | 0.80 | L3MBTL1 (0.66) | MAPK8MAPK10MAPK9L3MBTL1LMNA | |
| SCHEMBL25717208 | 0.80 | MAPK8 (0.54) | MAPK8MAPK10MAPK9L3MBTL1LMNA | |
| SCHEMBL10874779 | 0.79 | NPC1 (0.68) | MAPK10L3MBTL1LMNANPC1RAB9A | |
| SCHEMBL4154187 | 0.78 | MAPK8 (0.67) | MAPK8MAPK10MAPK9L3MBTL1LMNA | |
| SCHEMBL4779529 | 0.77 | ALDH1A1 (0.60) | MAPK8MAPK10MAPK9L3MBTL1LMNA | |
| SCHEMBL3555247 | 0.77 | NPC1 (0.58) | LMNACASP3NPC1RAB9AMAPK1 | |
| SCHEMBL3244736 | 0.77 | RAF1 (0.64) | L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | MAPK8 2493/4885MAPK10 1547/4885MAPK9 2149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.