Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11382483 | 0.86 | SMN1; SMN2 (0.42) | TRPM8SMN1; SMN2HPGDGAACES1 | |
| SCHEMBL11408368 | 0.82 | ALDH1A1 (0.33) | TRPM8SMN1; SMN2HPGDPPIDKMT2A | |
| SCHEMBL3689800 | 0.82 | ALDH1A1 (0.45) | SMN1; SMN2HPGDKMT2AMEN1HTT | |
| SCHEMBL11112769 | 0.81 | MEN1 (0.35) | TRPM8HPGDGAAPPIDKMT2A | |
| SCHEMBL2831671 | 0.79 | KMT2A (0.36) | SMN1; SMN2GAAPPIDKMT2AOPRM1 | |
| SCHEMBL13472597 | 0.75 | TRPM8 (0.56) | TRPM8SMN1; SMN2HPGDGAACES1 | |
| SCHEMBL6076551 | 0.74 | OPRM1 (0.45) | SMN1; SMN2CES1CES2KMT2AOPRM1 | |
| SCHEMBL11392628 | 0.73 | ALDH1A1 (0.31) | OPRM1TP53 | |
| SCHEMBL6206675 | 0.72 | TRPM8 (0.52) | TRPM8SMN1; SMN2HPGDGAACES1 | |
| SCHEMBL6949925 | 0.72 | TRPM8 (0.52) | TRPM8SMN1; SMN2HPGDGAACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1736471-B1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | MITSUI CHEMICALS AGRO INC (JP) | 2014-01-08 | — | — | EP | claimed |
| EP-0979034-B1 | COMPOSITION FOR CONTROLLING HARMFUL BIO-ORGANISMS AND METHOD FOR CONTROLLING HARMFUL BIO-ORGANISMS USING THE SAME | ISHIHARA SANGYO KAISHA (JP) | 2003-02-26 | — | — | EP | claimed |
| EP-1155616-B1 | Process for the preparation of (N-phenylacetyl-N-2,6-xylil)methyl alaninate | ISAGRO SPA (IT) | 2003-01-29 | — | — | EP | claimed |
| EP-1736471-B1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | MITSUI CHEMICALS AGRO INC (JP) | 2014-01-08 | — | — | EP | disclosed |
| EP-1926370-B1 | METHOD FOR PROTECTING PHYTOPATHOGENIC AGENTS BY KIRALAXYL, THE USE THEREOF AND USED SUBSTANCES | ISAGRO SPA (IT) | 2012-12-12 | — | — | EP | disclosed |
| EP-2514311-A1 | Method for protecting against phytopathogens with kiralaxyl, usage and means for same | ISAGRO S.p.A. (IT) | 2012-10-24 | — | — | EP | disclosed |
| EP-2514311-A1 | Method for protecting against phytopathogens with kiralaxyl, usage and means for same | ISAGRO S.p.A. (IT) | 2012-10-24 | — | — | EP | disclosed |
| EP-2514310-A1 | Method for protecting against phytopathogens with kiralaxyl, usage and means for same | ISAGRO S.p.A. (IT) | 2012-10-24 | — | — | EP | disclosed |
| EP-2514310-A1 | Method for protecting against phytopathogens with kiralaxyl, usage and means for same | ISAGRO S.p.A. (IT) | 2012-10-24 | — | — | EP | disclosed |
| US-7632783-B2 | fungicides, pesticides for protecting rice crop, tomatoes, cucumbers and green beans; 3-(5-fluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline | MITSUI CHEMICALS AGRO, INC. (JP) | 2009-12-15 | — | — | US | disclosed |
| US-20080275242-A1 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2008-11-06 | — | — | US | disclosed |
| US-20080039319-A1 | Fungicidal Mixtures and Novel Triazolopyrimidines | BASF AKTIENGESELLSCHAFT (DE) | 2008-02-14 | — | — | US | disclosed |
| WO-2007031283-A3 | METHOD FOR PROTECTING PHYTOPATHOGENIC AGENTS BY KIRALAXYL, THE USE THEREOF AND USED SUBSTANCES | BASF AG (DE) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007031283-A2 | METHOD FOR PROTECTING PHYTOPATHOGENIC AGENTS BY KIRALAXYL, THE USE THEREOF AND USED SUBSTANCES | BASF SE (DE) | 2007-03-22 | — | — | WO | disclosed |
| EP-1736471-A1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | Sankyo Agro Company, Limited (JP) | 2006-12-27 | — | — | EP | disclosed |
| EP-0669804-A1 | SYNERGISTIC MICROBICIDAL COMPOSITIONS | Novartis AG (CH) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994010845-A2 | SYNERGISTIC MICROBICIDAL COMPOSITIONS | CIBA-GEIGY AG (CH) | 1994-05-26 | — | — | WO | disclosed |
| US-5086048-A | 1,2,4-triazole of phenoxyether-ketones and phenoxyether-alkanols and copper complexes | BAYER AKTIENGESELLSCHAFT (DE) | 1992-02-04 | — | — | US | disclosed |
| US-4990528-A | Mixture of fungicidal agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | disclosed |
| US-4514402-A | 1,2,4-TRIAZOLE AND QUINOXALINE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275242-A1 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound | QTRT1, RABL3, RECQL | TRPM8 4447/4885SMN1; SMN2 3685/4885HPGD 3566/4885 |
| US-20080039319-A1 | Fungicidal Mixtures and Novel Triazolopyrimidines | ATIC, ARSA, AOC1 | TRPM8 4208/4885SMN1; SMN2 2245/4885HPGD 4408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.